Reactome | TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription

TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription

Stable Identifier

R-HSA-3215144

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)

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TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription

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Binding of TP53 (p53) to the p53 response element in the third intron of the GADD45A gene, together with chromatin modification mediated by TP53-associated proteins CARM1, PRMT1 and EP300, stimulates GADD45A transcription (An et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15186775	Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 An, W, Kim, J, Roeder, RG	Cell	2004

Participants

Input

GADD45A gene [nucleoplasm] (Homo sapiens)

Output

GADD45A [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

This event is regulated

Positively by

p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm]

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2013-03-15)