GADD45A gene transcription is stimulated by FOXO1, FOXO3 and FOXO4 (Tran et al. 2002, Furukawa-Hibi et al. 2002, Hughes et al. 2011, Sengupta et al. 2011, Ju et al. 2014). Direct transcriptional regulation was demonstrated for FOXO3 (Tran et al. 2002, Furukawa-Hibi et al. 2002) and FOXO4 (Furukawa-Hibi et al. 2002). Acetylation of FOXO4 by EP300 (p300) or CREBBP (CBP) in response to oxidative stress interferes with FOXO4-mediated induction of GADD45A gene transcription (Dansen et al. 2009). Under oxidative stress, deacetylation of FOXO3 by SIRT1 deacetylase promotes FOXO3-mediated induction of GADD45A gene transcription (Brunet et al. 2004).