Reactome | CHMP7 binds LEMD2

CHMP7 binds LEMD2

Stable Identifier

R-HSA-9668335

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
        
        CHMP7 binds LEMD2 (Homo sapiens)

General

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The ESCRT-III subunit CHMP7 binds LEMD2 (LEM2) at holes in the reforming nuclear envelope that are juxtaposed to the chromatin surface (Vietri et al 2015, Gu et al 2017).

Literature References

PubMed ID	Title	Journal	Year
28242692	LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells Frost, A, Gu, M, Redd, MJ, Ullman, KS, Ladinsky, MS, Sundquist, WI, Chen, OS, Bjorkman, PJ, Nikolova, L, LaJoie, D, von Appen, A	Proc. Natl. Acad. Sci. U.S.A.	2017