Reactome | SLC39A4 1223_1227del [plasma membrane]

SLC39A4 1223_1227del [plasma membrane]

Stable Identifier

R-HSA-5654119

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

hZIP4, Zinc transporter ZIP4, S39A4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q6P5W5 SLC39A4

Gene Names

SLC39A4, ZIP4

Chain

signal peptide:1-22, chain:23-647

Reference Genes

BioGPS Gene:55630 SLC39A4

COSMIC (genes):SLC39A4 SLC39A4

CTD Gene:55630 SLC39A4

dbSNP Gene:55630 SLC39A4

ENSEMBL:ENSG00000147804 SLC39A4

HGNC:17129 SLC39A4

KEGG:hsa:55630 SLC39A4

Monarch:55630 SLC39A4

NCBI Gene:55630 SLC39A4

OMIM:607059 SLC39A4

UCSC:Q6P5W5 SLC39A4

Reference Transcript

Other Identifiers

11754505_a_at

17082655

219215_PM_s_at

219215_s_at

3158574

3158575

3158576

3158580

3158582

3158583

3158584

3158585

3158586

3158587

3158588

3158589

3158590

3158591

3158592

3158593

3158594

3158595

3158596

3158598

3158600

3158601

3158602

3158603

3158604

3158605

3158606

3158607

3158608

46675_at

55630

8153762

A_23_P20502

A_24_P204954

A_33_P3240353

GE55446

GO:0005215

GO:0005385

GO:0005768

GO:0005886

GO:0006829

GO:0006882

GO:0008270

GO:0015701

GO:0016020

GO:0016324

GO:0030001

GO:0030003

GO:0031410

GO:0034224

GO:0042802

GO:0043226

GO:0046872

GO:0046873

GO:0055038

GO:0055085

GO:0071577

GO:0071578

GO:0106219

GO:0140299

GO:0140313

GO:0140410

GO:0140486

HMNXSV003000219

ILMN_1694801

ILMN_1715668

PH_hs_0035924

TC08001749.hg

g8923304_3p_a_at

Participates

as a member of

SLC39A4 mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

SLC39A4 [plasma membrane]

SLC39A4 L549del [plasma membrane]

SLC39A4 G330D [plasma membrane]

SLC39A4 P200L [plasma membrane]

SLC39A4 Q323Qfs*25 [plasma membrane]

SLC39A4 G512W [plasma membrane]

SLC39A4 G526R [plasma membrane]

SLC39A4 R95C [plasma membrane]

Modified Residues

Name

Deletion of residues 1223 to 1227

Disease

Name	Identifier	Synonyms
acrodermatitis enteropathica	DOID:0050605

Cross References

RefSeq

NP_060237.3, NP_060237.2, NP_570901.3, NP_570901.2

Guide to Pharmacology - Targets

1183

ENSEMBL

ENSP00000301305, ENSP00000276833, ENST00000276833, ENSG00000147804, ENST00000301305

OpenTargets

ENSG00000147804

GeneCards

SLC39A4

HPA

ENSG00000147804-SLC39A4

PRO

Q6P5W5

Pharos - Targets

Q6P5W5

GlyGen

Q6P5W5

Orphanet

SLC39A4

HMDB Protein

HMDBP11937

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.643	4
UniProt:Q9NRW7 VPS45	2	VPS45 [Golgi membrane] (R-HSA-6811025) VPS45 [endosome membrane] (R-HSA-1011607)	0.643	3
UniProt:P43304 GPD2	1	GPD2 [mitochondrial inner membrane] (R-HSA-188469)	0.527	2
UniProt:Q96AJ9 VTI1A	2	VTI1A [trans-Golgi network membrane] (R-HSA-6813927) VTI1A [Golgi membrane] (R-HSA-6811035)	0.527	2
UniProt:O00519 FAAH	1	FAAH [endoplasmic reticulum membrane] (R-HSA-5693746)	0.527	2
UniProt:Q16706 MAN2A1	2	MAN2A1 [transport vesicle] (R-HSA-8847487) MAN2A1 [Golgi membrane] (R-HSA-975823)	0.527	2
UniProt:O43909 EXTL3	2	EXTL3 [Golgi membrane] (R-HSA-9941179) EXTL3 [endoplasmic reticulum membrane] (R-HSA-535476)	0.527	2
UniProt:Q7Z7B1 PIGW	1	PIGW [endoplasmic reticulum membrane] (R-HSA-162693)	0.527	2
UniProt:Q9BYC5 FUT8	1	FUT8 [Golgi membrane] (R-HSA-1028782)	0.527	3
UniProt:Q9BTX1 NDC1	1	NDC1 [nuclear envelope] (R-HSA-6805183)	0.527	2
UniProt:O15228 GNPAT	3	GNPAT [cytosol] (R-HSA-9033129) GNPAT [peroxisomal membrane] (R-HSA-1500605) GNPAT [peroxisomal matrix] (R-HSA-53413)	0.527	2
UniProt:Q09328 MGAT5	1	MGAT5 [Golgi membrane] (R-HSA-975896)	0.527	2
UniProt:P17302 GJA1	7	GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544) GJA1 [plasma membrane] (R-HSA-158058) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [lysosomal membrane] (R-HSA-196173) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [Golgi membrane] (R-HSA-190649) p-S373-GJA1 [plasma membrane] (R-HSA-9857671)	0.527	2
UniProt:P26572 MGAT1	1	MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-964750)	0.527	2
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.527	3
UniProt:P17706 PTPN2	3	PTPN2 [nucleoplasm] (R-HSA-9008891) PTPN2 [cytosol] (R-HSA-997292) p-PTPN2 [cytosol] (R-HSA-9836510)	0.527	2
UniProt:O14975 SLC27A2	5	SLC27A2 [peroxisomal membrane] (R-HSA-389579) SLC27A2 [endoplasmic reticulum membrane] (R-HSA-193386) SLC27A2 [specific granule membrane] (R-HSA-6799565) SLC27A2 [plasma membrane] (R-HSA-6806316) SLC27A2 [cytosol] (R-HSA-9033090)	0.527	2
UniProt:Q14435 GALNT3	5	GALNT3 C574G [Golgi membrane] (R-HSA-6785545) GALNT3 Q592* [Golgi membrane] (R-HSA-6785551) GALNT3 T272K [Golgi membrane] (R-HSA-6785542) GALNT3 R162* [Golgi membrane] (R-HSA-6785543) GALNT3 [Golgi membrane] (R-HSA-913620)	0.527	2
UniProt:Q96K12 FAR2	1	FAR2 [peroxisomal membrane] (R-HSA-390430)	0.527	2

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