Reactome | CHRNA9 [plasma membrane]

CHRNA9 [plasma membrane]

Stable Identifier

R-HSA-507827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuronal acetylcholine receptor subunit alpha-9, ACHA9_HUMAN

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA9 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA9 [plasma membrane] (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA9 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UGM1 CHRNA9

Gene Names

CHRNA9, NACHRA9

Chain

signal peptide:1-25, chain:26-479

Reference Genes

BioGPS Gene:55584 CHRNA9

COSMIC (genes):CHRNA9 CHRNA9

CTD Gene:55584 CHRNA9

dbSNP Gene:55584 CHRNA9

ENSEMBL:ENSG00000174343 CHRNA9

HGNC:14079 CHRNA9

KEGG Gene (Homo sapiens):55584 CHRNA9

Monarch:55584 CHRNA9

NCBI Gene:55584 CHRNA9

OMIM:605116 CHRNA9

UCSC:Q9UGM1 CHRNA9

Reference Transcript

RefSeq:NM_017581.3 CHRNA9

Other Identifiers

0001170576

11737521_at

16966240

221107_at

2724735

2724736

2724737

2724738

2724739

2724745

2724748

2724749

2724750

55584

8094751

A_14_P202451

GE80696

GO:0003674

GO:0004888

GO:0005216

GO:0005230

GO:0005262

GO:0005515

GO:0005575

GO:0005886

GO:0005887

GO:0005892

GO:0006464

GO:0006810

GO:0006811

GO:0006812

GO:0006816

GO:0007165

GO:0007204

GO:0007267

GO:0007268

GO:0007605

GO:0008150

GO:0009790

GO:0016020

GO:0016021

GO:0022848

GO:0022857

GO:0030054

GO:0030594

GO:0032991

GO:0034220

GO:0042391

GO:0042472

GO:0042592

GO:0043005

GO:0043226

GO:0045202

GO:0045211

GO:0048856

GO:0050877

GO:0050910

GO:0055085

GO:0060078

GO:0060079

GO:0070373

GO:0070588

GO:0098981

GO:0099060

GO:1904315

HMNXSV003021936

ILMN_1728501

ILMN_2069286

PH_hs_0014044

TC04000245.hg

g8923741_3p_at

Participates

as a component of

CHRNA9:CHRNA10 [plasma membrane] (Homo sapiens)

as a member of

acetylcholine receptor subunits [plasma membrane] (Homo sapiens)

Inferred To

CHRNA9 [plasma membrane] (Bos taurus)

CHRNA9 [plasma membrane] (Canis familiaris)

CHRNA9 [plasma membrane] (Gallus gallus)

CHRNA9 [plasma membrane] (Sus scrofa)

Homologues of CHRNA9 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRNA9 [plasma membrane] (Danio rerio)

Chrna9 [plasma membrane] (Mus musculus)

Chrna9 [plasma membrane] (Rattus norvegicus)

chrna9a [plasma membrane] (Danio rerio)

chrna9 [plasma membrane] (Danio rerio)

chrna9 [plasma membrane] (Xenopus tropicalis)

lgc-4 [plasma membrane] (Caenorhabditis elegans)

lgc-31 [plasma membrane] (Caenorhabditis elegans)

acr-21 [plasma membrane] (Caenorhabditis elegans)

lgc-30 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_060051.2

Guide to Pharmacology - Targets

469

OpenTargets

ENSG00000174343

ZINC target

Q9UGM1

PRO

Q9UGM1

GlyGen

Q9UGM1

PDB

6HY7, 4UY2, 4UXU, 4D01

GeneCards

Q9UGM1

HPA

ENSG00000174343-CHRNA9

Ensembl

ENSG00000174343, ENSP00000312663, ENST00000310169

Pharos - Targets

Q9UGM1

Orphanet

26302

ZINC - Predictions - Purchasable

ACHA9_HUMAN

HMDB Protein

HMDBP07432