Reactome | CHRNA9 [plasma membrane]

CHRNA9 [plasma membrane]

Stable Identifier

R-HSA-507827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuronal acetylcholine receptor subunit alpha-9, ACHA9_HUMAN

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA9 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA9 [plasma membrane] (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA9 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UGM1 CHRNA9

Gene Names

CHRNA9, NACHRA9

Chain

signal peptide:1-25, chain:26-479

Reference Genes

BioGPS Gene:55584 CHRNA9

COSMIC (genes):CHRNA9 CHRNA9

CTD Gene:55584 CHRNA9

dbSNP Gene:55584 CHRNA9

ENSEMBL:ENSG00000174343 CHRNA9

HGNC:14079 CHRNA9

KEGG:hsa:55584 CHRNA9

Monarch:55584 CHRNA9

NCBI Gene:55584 CHRNA9

OMIM:605116 CHRNA9

UCSC:Q9UGM1 CHRNA9

Reference Transcript

RefSeq:NM_017581.3 CHRNA9

Other Identifiers

11737521_at

16966240

221107_PM_at

221107_at

2724735

2724736

2724737

2724738

2724739

2724743

2724744

2724745

2724746

2724748

2724749

2724750

55584

8094751

A_14_P202451

GE80696

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005262

GO:0005515

GO:0005886

GO:0005892

GO:0006811

GO:0006812

GO:0007154

GO:0007204

GO:0010996

GO:0016020

GO:0022848

GO:0023052

GO:0034220

GO:0042472

GO:0043005

GO:0045202

GO:0045211

GO:0050877

GO:0050910

GO:0051899

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0070588

GO:1902495

HMNXSV003021936

ILMN_1728501

ILMN_2069286

PH_hs_0014044

TC04000245.hg

g8923741_3p_at

Participates

as a component of

CHRNA9:CHRNA10 [plasma membrane] (Homo sapiens)

as a member of

acetylcholine receptor subunits [plasma membrane] (Homo sapiens)

Inferred To

CHRNA9 [plasma membrane] (Bos taurus)

CHRNA9 [plasma membrane] (Canis familiaris)

CHRNA9 [plasma membrane] (Gallus gallus)

CHRNA9 [plasma membrane] (Sus scrofa)

Homologues of CHRNA9 [plasma membrane] (Caenorhabditis elegans)

Chrna9 [plasma membrane] (Mus musculus)

Chrna9 [plasma membrane] (Rattus norvegicus)

lgc-7 [plasma membrane] (Caenorhabditis elegans)

lgc-9 [plasma membrane] (Caenorhabditis elegans)

lgc-4 [plasma membrane] (Caenorhabditis elegans)

lgc-12 [plasma membrane] (Caenorhabditis elegans)

lgc-31 [plasma membrane] (Caenorhabditis elegans)

lgc-6 [plasma membrane] (Caenorhabditis elegans)

acr-20 [plasma membrane] (Caenorhabditis elegans)

lgc-11 [plasma membrane] (Caenorhabditis elegans)

lgc-8 [plasma membrane] (Caenorhabditis elegans)

deg-3 [plasma membrane] (Caenorhabditis elegans)

acr-23 [plasma membrane] (Caenorhabditis elegans)

acr-5 [plasma membrane] (Caenorhabditis elegans)

lgc-10 [plasma membrane] (Caenorhabditis elegans)

acr-24 [plasma membrane] (Caenorhabditis elegans)

acr-21 [plasma membrane] (Caenorhabditis elegans)

lgc-5 [plasma membrane] (Caenorhabditis elegans)

des-2 [plasma membrane] (Caenorhabditis elegans)

lgc-30 [plasma membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

469

ENSEMBL

ENSP00000312663, ENSG00000174343, ENST00000310169

OpenTargets

ENSG00000174343

ZINC - Substances

ACHA9_HUMAN

ZINC target

Q9UGM1

PRO

Q9UGM1

GlyGen

Q9UGM1

PDB

4UXU, 6HY7, 4D01, 4UY2

GeneCards

CHRNA9

HPA

ENSG00000174343-CHRNA9

Pharos - Targets

Q9UGM1

ZINC - Predictions - Purchasable

ACHA9_HUMAN

HMDB Protein

HMDBP07432

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14757 CHEK1	3	p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838) CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285)	0.527	2
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:Q9Y6M5 SLC30A1	1	SLC30A1 [plasma membrane] (R-HSA-435361)	0.527	2
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.527	2
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [Golgi membrane] (R-HSA-9817559) SLC30A5 [secretory granule membrane] (R-HSA-437105)	0.527	2
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.527	2
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.527	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [specific granule membrane] (R-HSA-6799552) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [azurophil granule membrane] (R-HSA-6799559) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.527	2
UniProt:O15498 YKT6	5	PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558) PalmC-YKT6 [transport vesicle] (R-HSA-6808794) PalmC-YKT6 [Golgi membrane] (R-HSA-6808792)	0.527	2

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