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CHRNA3 [plasma membrane]
Stable Identifier
R-HSA-507838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuronal acetylcholine receptor subunit alpha-3, ACHA3_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Acetylcholine binding and downstream events (Homo sapiens)
Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)
0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
CHRNA3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32297 CHRNA3
Gene Names
CHRNA3, NACHRA3
Chain
signal peptide:1-31, chain:32-505
Reference Genes
BioGPS Gene:1136 CHRNA3
COSMIC - genes:CHRNA3 CHRNA3
CTD Gene:1136 CHRNA3
dbSNP Gene:1136 CHRNA3
ENSEMBL:ENSG00000080644 CHRNA3
HGNC:1957 CHRNA3
KEGG:hsa:1136 CHRNA3
Monarch:1136 CHRNA3
NCBI Gene:1136 CHRNA3
OMIM:118503 CHRNA3
UCSC:P32297 CHRNA3
Reference Transcript
RefSeq:NM_001166694.2 CHRNA3
RefSeq:NM_000743.4 CHRNA3
Other Identifiers
1136
11744551_a_at
11759134_a_at
11762756_at
11763526_x_at
16812174
17117661
210221_PM_at
210221_at
211587_PM_x_at
211587_x_at
211772_PM_x_at
211772_x_at
3344303
34019_at
3634657
3634658
3634661
3634662
3634663
3634664
3634665
3634666
3634667
3634669
3634670
3634671
3634672
3634673
3634674
3634675
3634676
3634677
54403_at
7990714
ADDON000283.hg
A_21_P0014916
A_23_P253911
A_33_P3388147
A_33_P3388148
GE57959
GO:0004888
GO:0005216
GO:0005230
GO:0005515
GO:0005730
GO:0005783
GO:0005794
GO:0005815
GO:0005829
GO:0005886
GO:0005892
GO:0006811
GO:0006940
GO:0007165
GO:0007271
GO:0007274
GO:0007399
GO:0007626
GO:0014056
GO:0015276
GO:0015464
GO:0016020
GO:0016607
GO:0022848
GO:0030425
GO:0034220
GO:0034703
GO:0035094
GO:0035095
GO:0036064
GO:0042166
GO:0042391
GO:0043005
GO:0043025
GO:0044853
GO:0045202
GO:0045211
GO:0048814
GO:0048856
GO:0051899
GO:0055085
GO:0060079
GO:0060084
GO:0095500
GO:0097060
GO:0098793
GO:0098878
GO:0099171
GO:1905144
HMNXSV003003856
HMNXSV003035688
ILMN_1794816
ILMN_2154157
M37981_at
M86383_s_at
PH_hs_0005003
TC15001705.hg
U62432_at
g12653482_3p_at
g13543945_3p_s_at
Participates
as a member of
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
as a component of
Acetylcholine receptor alpha3(2)-beta4(3) [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta2-aplha5 [plasma membrane] (Homo sapiens)
Acetylcholine receptor alpha3-beta4-apha5 [plasma membrane] (Homo sapiens)
Inferred To
chrna3 [plasma membrane]
(Xenopus tropicalis)
unc-63 [plasma membrane]
(Caenorhabditis elegans)
CHRNA3 [plasma membrane]
(Bos taurus)
CHRNA3 [plasma membrane]
(Canis familiaris)
CHRNA3 [plasma membrane]
(Gallus gallus)
CHRNA3 [plasma membrane]
(Mus musculus)
CHRNA3 [plasma membrane]
(Rattus norvegicus)
CHRNA3 [plasma membrane]
(Sus scrofa)
nAChRalpha1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001160166.1
,
NP_000734.2
ZINC - World Drugs
ACHA3_HUMAN
Guide to Pharmacology - Targets
464
ENSEMBL
ENST00000559658
,
ENSG00000080644
,
ENST00000326828
,
ENST00000348639
,
ENSP00000267951
,
ENSP00000315602
,
ENSP00000452896
OpenTargets
ENSG00000080644
ZINC - FDA approved
ACHA3_HUMAN
ZINC - Substances
ACHA3_HUMAN
ZINC - Biogenic
ACHA3_HUMAN
ZINC target
P32297
PRO
P32297
GlyGen
P32297
PDB
6PV7
,
6PV8
,
4ZK4
,
5TVC
,
5SYO
ZINC - Metabolites
ACHA3_HUMAN
GeneCards
CHRNA3
HPA
ENSG00000080644-CHRNA3
Pharos - Targets
P32297
ZINC - Predictions - Purchasable
ACHA3_HUMAN
HMDB Protein
HMDBP12047
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NC56 LEMD2
1
LEMD2 [nuclear envelope]
(R-HSA-3067329)
0.527
2
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