Reactome | DLK1 [plasma membrane]

DLK1 [plasma membrane]

Stable Identifier

R-HSA-1604447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Protein delta homolog 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P80370 DLK1

Gene Names

DLK1, DLK

Chain

signal peptide:1-23, chain:24-383, chain:24-303

Reference Genes

BioGPS Gene:8788 DLK1

COSMIC (genes):DLK1 DLK1

CTD Gene:8788 DLK1

dbSNP Gene:8788 DLK1

ENSEMBL:ENSG00000185559 DLK1

HGNC:2907 DLK1

KEGG:hsa:8788 DLK1

Monarch:8788 DLK1

NCBI Gene:8788 DLK1

OMIM:176290 DLK1

UCSC:P80370 DLK1

Reference Transcript

Other Identifiers

11744107_x_at

11753397_x_at

11753413_x_at

11757859_x_at

16788475

209560_PM_s_at

209560_s_at

235600_PM_at

235600_at

32648_at

3552082

3552084

3552085

3552086

3552088

3552089

3552090

3552092

3552093

3552094

3552095

3552096

3552098

3552100

3552102

3552104

7976783

8788

88597_at

A_14_P201244

A_24_P236251

A_33_P3217559

GE81328

GO:0005509

GO:0005515

GO:0005615

GO:0005737

GO:0016020

GO:0030154

GO:0045746

HMNXSV003044626

Hs.116631.0.A1_3p_at

ILMN_1652975

ILMN_1797519

PH_hs_0010091

PH_hs_0037735

TC14000644.hg

TC14001858.hg

g562105_3p_a_at

p33861

Participates

as a component of

NOTCH1:DLK1 [plasma membrane] (Homo sapiens)

as an input of

NOTCH1 binds DLK1 (Homo sapiens)

Cross References

RefSeq

NP_001304101.2, NP_003827.3

ZINC - World Drugs

DLK1_HUMAN

OpenTargets

ENSG00000185559

ENSEMBL

ENSP00000331081, ENSG00000185559, ENSP00000340292, ENST00000331224, ENST00000341267

ZINC - FDA approved

DLK1_HUMAN

ZINC - Substances

DLK1_HUMAN

ZINC target

P80370

PRO

P80370

GlyGen

P80370

GeneCards

DLK1

HPA

ENSG00000185559-DLK1

Pharos - Targets

P80370

Orphanet

DLK1

ZINC - Predictions - Purchasable

DLK1_HUMAN

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6NUQ4 TM214			0.643	3
UniProt:Q8N6S4 AN13C			0.643	4
UniProt:Q9BTV7 CABLES2	1	CABLES2 [cytosol] (R-HSA-1013845)	0.643	3
UniProt:Q6NSJ0 MYORG			0.643	4
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.643	3
UniProt:Q86YS7 C2CD5	2	p-S197-C2CD5 [plasma membrane] (R-HSA-5260194) C2CD5 [plasma membrane] (R-HSA-5216175)	0.643	3
UniProt:O60831 PRAF2			0.643	3
UniProt:Q7Z3V4 UBE3B	1	UBE3B [cytosol] (R-HSA-976043)	0.643	3
UniProt:P28799-2 GRN			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.527	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2
UniProt:P23458 JAK1	7	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) p-Y1034-JAK1 [endoplasmic reticulum lumen] (R-HSA-9931304)	0.527	2
UniProt:Q8TDN4 CABLES1	2	CABLES1 [cytosol] (R-HSA-1013859) CABLES1 [nucleoplasm] (R-HSA-1013870)	0.527	2
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.527	2
UniProt:Q9HD20 ATP13A1	1	ATP13A1 [endoplasmic reticulum membrane] (R-HSA-939749)	0.527	3
UniProt:O14733 MAP2K7	4	p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353) MAP2K7 [cytosol] (R-HSA-450276) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7(?-419) [cytosol] (R-HSA-5211401)	0.527	2
UniProt:Q9UIQ6 LNPEP	3	LNPEP [cytosol] (R-HSA-983098) LNPEP [early endosome lumen] (R-HSA-1236834) LNPEP [cytoplasmic vesicle membrane] (R-HSA-1445121)	0.527	2
UniProt:O14828 SCAM3			0.527	2
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.527	2
UniProt:Q4KMQ2 ANO6	3	ANO6 [tertiary granule membrane] (R-HSA-6800903) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [specific granule membrane] (R-HSA-6799509)	0.527	2
UniProt:Q9NRP0 OSTC	1	OSTC [endoplasmic reticulum membrane] (R-HSA-9932190)	0.527	2
UniProt:Q13705 ACVR2B	1	ACVR2B [plasma membrane] (R-HSA-201656)	0.527	2
UniProt:O43427 FIBP			0.527	2
UniProt:Q8NC42 RN149			0.527	2
UniProt:Q8WVC6 DCAKD	1	DCAKD [mitochondrial outer membrane] (R-HSA-9837353)	0.527	2
UniProt:A6NFQ2 TCAF2			0.527	2
UniProt:Q08345 DDR1	1	DDR1 [plasma membrane] (R-HSA-2327723)	0.527	2
UniProt:O43149 ZZEF1			0.527	2
UniProt:Q5SWX8 ODR4			0.527	2
UniProt:Q15012 LAP4A			0.527	2
UniProt:Q8WY22 BRI3B			0.527	3
UniProt:P98194 ATP2C1	1	ATP2C1 [Golgi membrane] (R-HSA-936898)	0.527	2
UniProt:Q12767 TMM94			0.527	2
UniProt:Q9UHF1 EGFL7			0.527	2
UniProt:Q9NVM1 EVA1B			0.527	2
UniProt:Q86VI4 LAP4B			0.527	2
UniProt:Q8IZ07 AN13A			0.527	2
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:P10586 PTPRF	2	PTPRF [endosome membrane] (R-HSA-9815889) PTPRF [plasma membrane] (R-HSA-6786486)	0.527	2

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