Reactome | DLK1 [plasma membrane]

DLK1 [plasma membrane]

Stable Identifier

R-HSA-1604447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Protein delta homolog 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P80370 DLK1

Gene Names

DLK1, DLK

Chain

signal peptide:1-23, chain:24-383, chain:24-303

Reference Genes

BioGPS Gene:8788 DLK1

COSMIC (genes):DLK1 DLK1

CTD Gene:8788 DLK1

dbSNP Gene:8788 DLK1

ENSEMBL:ENSG00000185559 DLK1

HGNC:2907 DLK1

KEGG:hsa:8788 DLK1

Monarch:8788 DLK1

NCBI Gene:8788 DLK1

OMIM:176290 DLK1

UCSC:P80370 DLK1

Reference Transcript

Other Identifiers

11744107_x_at

11753397_x_at

11753413_x_at

11757859_x_at

16788475

209560_PM_s_at

209560_s_at

235600_PM_at

235600_at

32648_at

3552084

3552085

3552086

3552088

3552089

3552090

3552092

3552093

3552094

3552095

3552096

3552098

3552100

3552102

3552104

7976783

8788

88597_at

A_14_P122464

A_14_P201244

A_24_P236251

A_33_P3217559

GE81328

GO:0003674

GO:0005509

GO:0005515

GO:0005615

GO:0005737

GO:0016020

GO:0030154

GO:0045746

HMNXSV003044626

Hs.116631.0.A1_3p_at

ILMN_1652975

ILMN_1797519

PH_hs_0010091

PH_hs_0037735

TC14000644.hg

TC14001858.hg

g562105_3p_a_at

p33861

Participates

as a component of

NOTCH1:DLK1 [plasma membrane] (Homo sapiens)

as an input of

NOTCH1 binds DLK1 (Homo sapiens)

Cross References

RefSeq

NP_001304101.1, NP_003827.3

ZINC - World Drugs

DLK1_HUMAN

OpenTargets

ENSG00000185559

ENSEMBL

ENST00000331224, ENSP00000340292, ENST00000341267, ENSP00000331081

ZINC - FDA approved

DLK1_HUMAN

ZINC - Substances

DLK1_HUMAN

ZINC target

P80370

PRO

P80370

GlyGen

P80370

HPA

ENSG00000185559-DLK1

Pharos - Targets

P80370

Orphanet

DLK1

ZINC - Predictions - Purchasable

DLK1_HUMAN

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799-2 GRN			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q8WVC6 DCAKD	1	DCAKD [mitochondrial outer membrane] (R-HSA-9837353)	0.527	2
UniProt:Q8TDN4 CABLES1	2	CABLES1 [cytosol] (R-HSA-1013859) CABLES1 [nucleoplasm] (R-HSA-1013870)	0.527	2
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.527	2
UniProt:Q6NUQ4 TM214			0.527	2
UniProt:Q6NSJ0 MYORG			0.527	3
UniProt:Q8N6S4 AN13C			0.527	3
UniProt:Q4KMQ2 ANO6	3	ANO6 [tertiary granule membrane] (R-HSA-6800903) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [specific granule membrane] (R-HSA-6799509)	0.527	2
UniProt:Q9NRP0 OSTC			0.527	2
UniProt:Q13705 ACVR2B	1	ACVR2B [plasma membrane] (R-HSA-201656)	0.527	2
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.527	2
UniProt:Q9UHF1 EGFL7			0.527	2
UniProt:A6NFQ2 TCAF2			0.527	2
UniProt:Q9NVM1 EVA1B			0.527	2
UniProt:Q86YS7 C2CD5	2	C2CD5 [plasma membrane] (R-HSA-5216175) p-S197-C2CD5 [plasma membrane] (R-HSA-5260194)	0.527	2
UniProt:Q9BTV7 CABLES2	1	CABLES2 [cytosol] (R-HSA-1013845)	0.527	2
UniProt:O60831 PRAF2			0.527	2
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:Q8WY22 BRI3B			0.527	3
UniProt:Q7Z3V4 UBE3B	1	UBE3B [cytosol] (R-HSA-976043)	0.527	2

© 2025 Reactome

Cite Us!