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DET1 [cytosol]
Stable Identifier
R-HSA-976007
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DET1 homolog, DET1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
DET1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7L5Y6 DET1
Gene Names
DET1
Chain
chain:1-550
Reference Genes
BioGPS Gene:55070 DET1
COSMIC (genes):DET1 DET1
CTD Gene:55070 DET1
dbSNP Gene:55070 DET1
ENSEMBL:ENSG00000140543 DET1
ENSEMBL_homo_sapiens_GENE:ENSG00000140543.15 DET1
HGNC:25477 DET1
KEGG Gene (Homo sapiens):55070 DET1
Monarch:55070 DET1
NCBI Gene:55070 DET1
OMIM:608727 DET1
UCSC:Q7L5Y6 DET1
Reference Transcript
RefSeq:NM_017996.4 DET1
RefSeq:NM_001144074.2 DET1
RefSeq:NM_001321596.1 DET1
Other Identifiers
11736589_a_at
11755361_a_at
16812997
219641_PM_at
219641_at
3638075
3638076
3638077
3638078
3638079
3638080
3638084
3638086
3638087
3638088
3638089
3638090
3638091
3638092
53528_at
55070
7991216
A_23_P26184
GE55663
GO:0005515
GO:0005634
GO:0016567
GO:0030163
GO:0031461
GO:0031464
GO:0031625
GO:0032436
GO:0036211
GO:0043226
GO:0044877
GO:0060090
GO:0065003
GO:0080008
GO:1990756
HMNXSV003033667
HMNXSV003048130
HMNXSV003055512
ILMN_1661653
ILMN_2145423
PH_hs_0003094
TC15001818.hg
TC15002693.hg
g8922230_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
DET1 [cytosol]
(Bos taurus)
DET1 [cytosol]
(Canis familiaris)
DET1 [cytosol]
(Dictyostelium discoideum)
DET1 [cytosol]
(Gallus gallus)
DET1 [cytosol]
(Plasmodium falciparum)
DET1 [cytosol]
(Sus scrofa)
det1 [cytosol]
(Danio rerio)
det1 [cytosol]
(Xenopus tropicalis)
Det1 [cytosol]
(Mus musculus)
Det1 [cytosol]
(Rattus norvegicus)
abo [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001308525.1
,
NP_060466.2
,
NP_001137546.1
OpenTargets
ENSG00000140543
GeneCards
Q7L5Y6
HPA
ENSG00000140543-DET1
Ensembl
ENST00000268148
,
ENSP00000408994
,
ENSG00000140543
,
ENST00000444300
,
ENSP00000268148
,
ENSP00000456340
,
ENST00000564406
PRO
Q7L5Y6
Pharos - Targets
Q7L5Y6
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96RU8 TRIB1
1
TRIB1 [cytosol]
(R-HSA-9621338)
0.643
4
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.527
2
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.527
2
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