Reactome | BRCC3 [nucleoplasm]

BRCC3 [nucleoplasm]

Stable Identifier

R-HSA-5682577

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lys-63-specific deubiquitinase BRCC36, BRCC36

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - CHEK2 is recruited to DNA DSBs (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
      - Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - CHEK2 is recruited to DNA DSBs (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
      - CHEK2 phosphorylates BRCA1 (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
      - Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
      - Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        PIAS4 SUMOylates MDC1 (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        RNF4 ubiquitinates MDC1 (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)
  - Nonhomologous End-Joining (NHEJ) (Homo sapiens)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
      - BRCC3 [nucleoplasm] (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
        
        BRCC3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46736 BRCC3

Gene Names

BRCC3, BRCC36, C6.1A, CXorf53

Chain

initiator methionine:1, chain:2-316

Reference Genes

BioGPS Gene:79184 BRCC3

COSMIC (genes):BRCC3 BRCC3

CTD Gene:79184 BRCC3

dbSNP Gene:79184 BRCC3

ENSEMBL:ENSG00000185515 BRCC3

HGNC:24185 BRCC3

KEGG Gene (Homo sapiens):79184 BRCC3

Monarch:79184 BRCC3

NCBI Gene:79184 BRCC3

OMIM:300617 BRCC3

UCSC:P46736 BRCC3

Reference Transcript

Other Identifiers

0104050102

11726529_s_at

11726530_x_at

11726531_x_at

11733210_x_at

11733211_x_at

11750003_s_at

17108546

216521_s_at

221196_x_at

229436_x_at

231913_s_at

2842475

2842476

2842477

2842478

2842481

3996756

3996757

3996759

3996760

3996761

3996764

3996766

3996767

3996768

3996777

3996778

3996780

3996783

3996785

79184

8171006

A_23_P217659

A_33_P3303940

A_33_P3385461

GE59908

GO:0000151

GO:0000152

GO:0000922

GO:0003674

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006259

GO:0006281

GO:0006302

GO:0006303

GO:0006325

GO:0006464

GO:0006508

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0008150

GO:0008233

GO:0008237

GO:0010165

GO:0010212

GO:0016579

GO:0016787

GO:0030234

GO:0031593

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0045739

GO:0046872

GO:0050790

GO:0051276

GO:0051301

GO:0070122

GO:0070531

GO:0070536

GO:0070537

GO:0070552

GO:0072425

HMNXSV003007440

HMNXSV003018106

Hs.301927.1.A1_3p_a_at

Hs.301927.2.S1_3p_a_at

ILMN_1697546

ILMN_1700026

ILMN_1744613

PH_hs_0027362

TC0X000783.hg

TC0X001943.hg

X64643_at

Participates

as an output of

as a component of

as an input of

Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)

Other forms of this molecule

BRCC3 [cytosol]

Inferred To

BRCC3 [nucleoplasm] (Canis familiaris)

BRCC3 [nucleoplasm] (Gallus gallus)

BRCC3 [nucleoplasm] (Sus scrofa)

brcc3 [nucleoplasm] (Danio rerio)

brcc3 [nucleoplasm] (Xenopus tropicalis)

Brcc3 [nucleoplasm] (Mus musculus)

Brcc3 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001229569.1, NP_001018065.1, NP_077308.1, XP_016885327.1

OpenTargets

ENSG00000185515

HPA

ENSG00000185515-BRCC3

GeneCards

P46736

Ensembl

ENSP00000358471, ENSG00000185515, ENST00000369459, ENSP00000344103, ENST00000340647, ENSP00000358474, ENST00000330045, ENST00000369462, ENSP00000328641

PRO

P46736

Pharos - Targets

P46736

Orphanet

20200

GlyGen

P46736

PDB

6H3C, 6R8F

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96RL1-1 UIMC1			0.688	4
UniProt:Q6UWZ7 ABRAXAS1	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.656	4
UniProt:Q9NXR7 BABAM2	2	BRE [cytosol] (R-HSA-5691413) BRE [nucleoplasm] (R-HSA-5682579)	0.589	3
UniProt:X5D778 X5D778			0.556	3
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.483	2

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