Reactome | FOSL1 [nucleoplasm]

FOSL1 [nucleoplasm]

Stable Identifier

R-HSA-9620405

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fos-related antigen 1, FOSL1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        AP-1 binds ARC gene (Homo sapiens)
        
        AP-1 dimers [nucleoplasm] (Homo sapiens)
        
        FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
        
        FOSL1 [nucleoplasm] (Homo sapiens)
        
        AP-1 dimers:ARC gene [nucleoplasm] (Homo sapiens)
        
        AP-1 dimers [nucleoplasm] (Homo sapiens)
        
        FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
        
        FOSL1 [nucleoplasm] (Homo sapiens)
        
        ARC gene expression (Homo sapiens)
        
        AP-1 dimers:ARC gene [nucleoplasm] (Homo sapiens)
        
        AP-1 dimers [nucleoplasm] (Homo sapiens)
        
        FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)
        
        FOSL1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15407 FOSL1

Gene Names

FOSL1, FRA1

Chain

chain:1-271

Reference Genes

BioGPS Gene:8061 FOSL1

COSMIC (genes):FOSL1 FOSL1

CTD Gene:8061 FOSL1

dbSNP Gene:8061 FOSL1

ENSEMBL:ENSG00000175592 FOSL1

HGNC:13718 FOSL1

KEGG:hsa:8061 FOSL1

Monarch:8061 FOSL1

NCBI Gene:8061 FOSL1

OMIM:136515 FOSL1

UCSC:P15407 FOSL1

Reference Transcript

Other Identifiers

11724477_a_at

11724478_s_at

11724479_x_at

11760284_a_at

11760573_a_at

11760574_x_at

16740630

204420_PM_at

204420_at

213250_PM_at

2743142

2743143

3377992

3377993

3377994

3377995

3377996

3378000

3378003

3378004

3378005

7949532

8061

A_23_P161624

A_23_P322519

GE79056

GE88427

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0001701

GO:0002224

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0006935

GO:0006954

GO:0006968

GO:0007296

GO:0007565

GO:0007612

GO:0008284

GO:0008285

GO:0009410

GO:0009611

GO:0009612

GO:0009615

GO:0009629

GO:0010467

GO:0014070

GO:0019221

GO:0022414

GO:0032570

GO:0034097

GO:0042542

GO:0042734

GO:0043065

GO:0043226

GO:0045787

GO:0045944

GO:0048856

GO:0050877

GO:0051412

GO:0051591

GO:0060674

GO:0090575

GO:0140110

GO:0140467

GO:1902895

GO:1990837

GO:1990841

GO:2000144

HMNXSV003041454

Hs.283565.0.A2_3p_at

Hs.66713.1.A1_3p_at

Hs.66713.1.A1_3p_x_at

ILMN_1771841

PH_hs_0029612

TC11001948.hg

X16707_at

Participates

as a member of

FOS, FOSB, FOSL1, JUNB, JUND [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001287785.1, NP_005429.1, NP_001287786.1, NP_001287784.1, NP_001287773.1

ENSEMBL

ENST00000448083, ENSP00000310170, ENST00000312562, ENSP00000393302

OpenTargets

ENSG00000175592

HPA

ENSG00000175592-FOSL1

PRO

P15407

Pharos - Targets

P15407

GlyGen

P15407

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.855	11
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.806	12
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.782	7
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.59	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.462	2