Reactome | BRCC3 [cytosol]

BRCC3 [cytosol]

Stable Identifier

R-HSA-5691415

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Lys-63-specific deubiquitinase BRCC36, BRCC36

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Metalloprotease DUBs (Homo sapiens)
      - BRISC complex deubiquitinates NLRP3 (Homo sapiens)
        
        BRISC complex:K63polyUb-NLRP3 [cytosol] (Homo sapiens)
        
        BRISC complex [cytosol] (Homo sapiens)
        
        BRCC3 [cytosol] (Homo sapiens)
        
        BRISC complex:NLRP3 [cytosol] (Homo sapiens)
        
        BRISC complex [cytosol] (Homo sapiens)
        
        BRCC3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46736 BRCC3

Gene Names

BRCC3, BRCC36, C6.1A, CXorf53

Chain

initiator methionine:, chain:2-316

Reference Genes

BioGPS Gene:79184 BRCC3

COSMIC (genes):BRCC3 BRCC3

CTD Gene:79184 BRCC3

dbSNP Gene:79184 BRCC3

ENSEMBL:ENSG00000185515 BRCC3

HGNC:24185 BRCC3

KEGG:hsa:79184 BRCC3

Monarch:79184 BRCC3

NCBI Gene:79184 BRCC3

OMIM:300617 BRCC3

UCSC:P46736 BRCC3

Reference Transcript

Other Identifiers

11726529_s_at

11726530_x_at

11726531_x_at

11733210_x_at

11733211_x_at

11750003_s_at

17108546

216521_PM_s_at

216521_s_at

221196_PM_x_at

221196_x_at

229436_PM_x_at

229436_x_at

231913_PM_s_at

231913_s_at

2842475

2842476

2842477

2842478

2842481

3996756

3996757

3996759

3996760

3996761

3996764

3996765

3996766

3996767

3996768

3996777

3996778

3996780

3996783

3996785

3996787

79184

8171006

84347_s_at

A_23_P217659

A_33_P3303940

A_33_P3385453

A_33_P3385461

GE59908

GO:0000151

GO:0000152

GO:0000922

GO:0003824

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006281

GO:0006282

GO:0006302

GO:0006325

GO:0006508

GO:0007095

GO:0008233

GO:0008237

GO:0010165

GO:0010212

GO:0016579

GO:0016787

GO:0030234

GO:0031593

GO:0043226

GO:0044818

GO:0045739

GO:0046872

GO:0051301

GO:0061578

GO:0070531

GO:0070536

GO:0070552

GO:0071479

GO:0098772

GO:0140096

GO:0140492

GO:0140861

GO:1900227

GO:2000001

HMNXSV003007440

HMNXSV003018106

HMNXSV003047704

Hs.301927.1.A1_3p_a_at

Hs.301927.2.S1_3p_a_at

ILMN_1697546

ILMN_1700026

PH_hs_0027362

TC0X000783.hg

TC0X001943.hg

X64643_at

Participates

as a component of

BRISC complex [cytosol] (Homo sapiens)

Other forms of this molecule

BRCC3 [nucleoplasm]

Inferred To

BRCC3 [cytosol] (Bos taurus)

BRCC3 [cytosol] (Gallus gallus)

BRCC3 [cytosol] (Mus musculus)

BRCC3 [cytosol] (Rattus norvegicus)

BRCC3 [cytosol] (Sus scrofa)

BRCC3 [cytosol] (Xenopus tropicalis)

FUNDC2 [cytosol] (Canis familiaris)

Cross References

RefSeq

XP_016885327.1, NP_001229569.1, NP_001018065.1, NP_077308.1

ENSEMBL

ENST00000369462, ENSP00000344103, ENST00000340647, ENSP00000358471, ENSP00000328641, ENST00000330045, ENST00000369459, ENSP00000358474

OpenTargets

ENSG00000185515

HPA

ENSG00000185515-BRCC3

PRO

P46736

Pharos - Targets

P46736

GlyGen

P46736

Orphanet

BRCC3

HMDB Protein

HMDBP13773

PDB

6R8F, 6H3C

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34897 SHMT2	2	PXLP-K280-SHMT2 [mitochondrial inner membrane] (R-HSA-5694086) SHMT2 [cytosol] (R-HSA-9714752)	0.723	4
UniProt:Q15018 FAM175B	1	FAM175B [cytosol] (R-HSA-5691428)	0.695	8
UniProt:Q96RL1-1 UIMC1			0.688	4
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.669	4
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.641	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.615	3
UniProt:X5D778 X5D778			0.556	3
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.527	4