NPM-ALK-dependent JUNB translation

Stable Identifier
R-HSA-9725345
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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In addition to transcriptional control, NPM-ALK regulates the expression of JUNB at the protein level through the PI3K/AKT/mTOR signaling pathways. Treatment of cells with rapamycin, which prevents the phosphorylation of RPS6KB1 (also known as p70S6 kinase) and RPS6, blocks translational activation of 5'-TOP mRNAs including JUNB (Staber et al, 2007).

Literature References
PubMed ID Title Journal Year
17690253 The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

Ott, RG, Hrzenjak, A, Linkesch, W, Bambach, I, Bergler, H, Haq, N, Fuchs, C, Funato, K, Dirks, WG, Vesely, P, Sexl, V, Schauer, S, Staber, PB, Kadin, ME, Kenner, L, Sternberg, DW, Hoefler, G

Blood 2007
Participants
Participates
This event is regulated
Positively by
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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