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RAD18 [nucleoplasm]
Stable Identifier
R-HSA-5643731
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase RAD18, RNF73, RING finger protein 73
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B [nucleoplasm] (Homo sapiens)
RAD18 homodimer [nucleoplasm] (Homo sapiens)
RAD18 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NS91 RAD18
Gene Names
RAD18, RNF73
Chain
chain:1-495
Reference Genes
BioGPS Gene:56852 RAD18
COSMIC (genes):RAD18 RAD18
CTD Gene:56852 RAD18
dbSNP Gene:56852 RAD18
ENSEMBL:ENSG00000070950.10 RAD18
HGNC:18278 RAD18
KEGG Gene (Homo sapiens):56852 RAD18
Monarch:56852 RAD18
NCBI Gene:56852 RAD18
OMIM:605256 RAD18
UCSC:Q9NS91 RAD18
Reference Transcript
RefSeq:NM_020165.3 RAD18
Other Identifiers
0102650685
11728257_at
11756973_a_at
16950448
223417_3p_at
223417_PM_at
223417_at
224200_PM_s_at
224200_s_at
238670_PM_at
238670_at
238748_PM_at
238748_at
2662026
2662027
2662028
2662029
2662030
2662031
2662032
2662033
2662035
2662041
2662042
2662044
2662045
2662047
2662049
2662054
2662055
2662056
2662057
2662059
2662060
2662061
56852
58202_at
59693_at
8085145
80852_at
A_23_P121222
GE82508
GO:0000403
GO:0003677
GO:0003684
GO:0003697
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006301
GO:0006513
GO:0006974
GO:0007059
GO:0016567
GO:0016604
GO:0016740
GO:0031593
GO:0031625
GO:0032991
GO:0035861
GO:0036211
GO:0042405
GO:0042802
GO:0043226
GO:0044877
GO:0046872
GO:0051865
GO:0051984
GO:0060548
GO:0061630
GO:0097505
GO:0098772
GO:0140096
GO:0140678
HMNXSV003057176
Hs.134542.0.A1_3p_at
Hs.287323.0.A1_3p_at
ILMN_1707548
ILMN_2084391
PH_hs_0024252
TC03001146.hg
TC03002794.hg
g8895211_3p_at
g8895211_3p_s_at
g8895211_3p_x_at
g8980616_3p_a_at
g8980616_3p_x_at
Participates
as a component of
RAD18 homodimer [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of RAD18 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of RAD18 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of RAD18 [nucleoplasm]
(Plasmodium falciparum)
RAD18 [nucleoplasm]
(Bos taurus)
RAD18 [nucleoplasm]
(Canis familiaris)
RAD18 [nucleoplasm]
(Danio rerio)
RAD18 [nucleoplasm]
(Gallus gallus)
RAD18 [nucleoplasm]
(Mus musculus)
RAD18 [nucleoplasm]
(Schizosaccharomyces pombe)
RAD18 [nucleoplasm]
(Sus scrofa)
Rad18 [nucleoplasm]
(Rattus norvegicus)
rad18 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_064550.3
OpenTargets
ENSG00000070950
GeneCards
Q9NS91
HPA
ENSG00000070950-RAD18
Ensembl
ENSG00000070950
,
ENST00000264926
,
ENSP00000264926
PRO
Q9NS91
Pharos - Targets
Q9NS91
PDB
2MRF
,
2Y43
,
2MRE
,
2YBF
,
5VF0
HMDB Protein
HMDBP09297
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14527 HLTF
1
HLTF [nucleoplasm]
(R-HSA-8855007)
0.623
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.556
3
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