SMAD2/3:SMAD4 complex positively regulates JUNB transcription

Stable Identifier
R-HSA-2187293
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMAD2/3:SMAD4 complex positively regulates JUNB transcription
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SMAD2/3:SMAD4 heterotrimer binds SMAD binding site in the promoter of JUNB transcription factor and in cooperation with AP-1 transcription factors, which bind to an adjacent promoter element, stimulates transcription of JUNB gene (Wong et al. 1999).

Literature References
PubMed ID Title Journal Year
10022869 Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

Wong, C, Rougier-Chapman, EM, Frederick, JP, Datto, MB, Liberati, NT, Li, JM, Wang, XF

Mol Cell Biol 1999
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-09)