SMAD2/3:SMAD4 complex positively regulates JUNB transcription

Stable Identifier
R-HSA-2187293
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD2/3:SMAD4 complex positively regulates JUNB transcription
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SMAD2/3:SMAD4 heterotrimer binds SMAD binding site in the promoter of JUNB transcription factor and in cooperation with AP-1 transcription factors, which bind to an adjacent promoter element, stimulates transcription of JUNB gene (Wong et al. 1999).
Literature References
PubMed ID Title Journal Year
10022869 Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

Wong, C, Wang, XF, Datto, MB, Rougier-Chapman, EM, Li, JM, Liberati, NT, Frederick, JP

Mol Cell Biol 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-2S-SMAD2,3:SMAD4:JUNB gene [nucleoplasm] (Homo sapiens)
Active Unit
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-09)
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