Reactome | IL7R [plasma membrane]

IL7R [plasma membrane]

Stable Identifier

R-HSA-449945

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IL7RA, Interleukin-7 receptor subunit alpha, IL7R_HUMAN, CD127

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Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - AP-2 directly binds some endocytic cargo (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        IL7R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16871 IL7R

Gene Names

IL7R

Chain

signal peptide:1-20, chain:21-459

Reference Genes

BioGPS Gene:3575 IL7R

COSMIC (genes):IL7R IL7R

CTD Gene:3575 IL7R

dbSNP Gene:3575 IL7R

ENSEMBL:ENSG00000168685 IL7R

HGNC:6024 IL7R

KEGG:hsa:3575 IL7R

Monarch:3575 IL7R

NCBI Gene:3575 IL7R

OMIM:146661 IL7R

UCSC:P16871 IL7R

Reference Transcript

Other Identifiers

11733187_a_at

11751647_a_at

11762266_x_at

1370_at

16984010

205798_PM_at

205798_at

226218_PM_at

226218_at

2806469

2806470

2806471

2806472

2806474

2806475

2806477

2806479

2806480

2806481

2806484

2806485

2806486

2806487

2806489

3575

36227_at

59289_at

63628_at

63629_g_at

8104901

A_23_P404494

GE61487

GE81130

GO:0000018

GO:0000902

GO:0001782

GO:0001913

GO:0001915

GO:0002376

GO:0003823

GO:0004896

GO:0004917

GO:0005515

GO:0005576

GO:0005654

GO:0005829

GO:0005886

GO:0006955

GO:0007165

GO:0007166

GO:0008284

GO:0008361

GO:0009897

GO:0010467

GO:0010628

GO:0016020

GO:0019221

GO:0019725

GO:0030097

GO:0030154

GO:0030217

GO:0030669

GO:0033077

GO:0033089

GO:0038111

GO:0042100

GO:0043029

GO:0046427

GO:0048535

GO:0048856

GO:0050830

GO:0070233

GO:0098542

GO:1904894

HMNXSV003027352

HMNXSV003030764

Hs.237868.1.S1_3p_at

ILMN_1691341

ILMN_2342579

M29696_at

PH_hs_0017371

TC05000159.hg

g4504678_3p_at

Participates

as a component of

as a member of

AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)

as an input of

JAK1 binds IL7R (Homo sapiens)

Other forms of this molecule

p-Y449-IL7R [plasma membrane]

IL7R [clathrin-coated endocytic vesicle membrane]

Inferred To

il7r [plasma membrane] (Danio rerio)

il7r [plasma membrane] (Xenopus tropicalis)

IL7R [plasma membrane] (Bos taurus)

IL7R [plasma membrane] (Canis familiaris)

IL7R [plasma membrane] (Gallus gallus)

IL7R [plasma membrane] (Sus scrofa)

Il7r [plasma membrane] (Mus musculus)

Il7r [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_047273106.1, NP_002176.2

Guide to Pharmacology - Targets

1698

OpenTargets

ENSG00000168685

ENSEMBL

ENSP00000306157, ENSP00000421207, ENSG00000168685, ENST00000506850, ENST00000303115

HPA

ENSG00000168685-IL7R

GeneCards

IL7R

PRO

P16871

Pharos - Targets

P16871

Orphanet

IL7R

GlyGen

P16871

PDB

6P67, 3DI2, 3UP1, 5J11, 3DI3, 7OPB, 6P50

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13232 IL7	1	IL7 [extracellular region] (R-HSA-447209)	0.737	10
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q8IX05 CD302			0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:P11836 CD20			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:P31431 SDC4	20	HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674) HS(5)-SDC4 [plasma membrane] (R-HSA-2076635) Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064249) Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064100) XylS-SDC4 [Golgi lumen] (R-HSA-2064195) SDC4 [Golgi lumen] (R-HSA-2054111) GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064067) HS(5)-SDC4 [Golgi lumen] (R-HSA-2076510) HS(6)-SDC4 [Golgi lumen] (R-HSA-2076330) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446)	0.556	3
UniProt:Q92520 FAM3C	2	FAM3C [platelet dense granule lumen] (R-HSA-8848884) FAM3C [extracellular region] (R-HSA-8848922)	0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:O95236-2 APOL3			0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:A0PK00 T120B			0.556	3
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	2
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.471	5

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