Reactome | PXLP-SGPL1 [endoplasmic reticulum membrane]

PXLP-SGPL1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428661

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SGPL1, sphingosine-1-phosphate lyase 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95470 SGPL1

Gene Names

SGPL1, KIAA1252

Chain

chain:1-568

Reference Genes

BioGPS Gene:8879 SGPL1

COSMIC (genes):SGPL1 SGPL1

CTD Gene:8879 SGPL1

dbSNP Gene:8879 SGPL1

ENSEMBL:ENSG00000166224 SGPL1

ENSEMBL:ENSG00000166224.18 SGPL1

HGNC:10817 SGPL1

KEGG Gene (Homo sapiens):8879 SGPL1

Monarch:8879 SGPL1

NCBI Gene:8879 SGPL1

OMIM:603729 SGPL1

UCSC:O95470 SGPL1

Reference Transcript

Other Identifiers

11719958_at

11719959_at

16705778

208381_PM_s_at

208381_s_at

212321_PM_at

212321_at

212322_PM_at

212322_at

3250864

3250865

3250866

3250867

3250871

3250873

3250874

3250875

3250876

3250877

3250883

3250885

3250887

3250888

3250890

3250892

3250893

3250896

3250897

3250898

3250899

35875_at

35876_s_at

44046_at

63400_at

7928171

8879

A_14_P106979

A_14_P125528

A_14_P126970

A_14_P127175

A_23_P75325

A_24_P940815

A_33_P3327847

GE62800

GE80468

GO:0001553

GO:0001570

GO:0001822

GO:0002376

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006631

GO:0006665

GO:0006672

GO:0006807

GO:0006915

GO:0007283

GO:0008117

GO:0008209

GO:0008210

GO:0008585

GO:0009791

GO:0010761

GO:0012501

GO:0016020

GO:0016829

GO:0016830

GO:0019752

GO:0022414

GO:0023052

GO:0030097

GO:0030148

GO:0030149

GO:0030154

GO:0030170

GO:0033327

GO:0040014

GO:0043226

GO:0048008

GO:0048705

GO:0048856

GO:0048870

GO:0060021

GO:0060325

GO:0097190

HMNXSV003040056

Hs.186613.1.S2_3p_at

Hs.186613.1.S3_3p_at

ILMN_1761531

PH_hs_0010928

TC10000434.hg

TC10002114.hg

g10190652_3p_a_at

Inferred To

spl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

DPL1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

PXLP-SGPL1 [endoplasmic reticulum membrane] (Canis familiaris)

PXLP-SGPL1 [endoplasmic reticulum membrane] (Gallus gallus)

SGPL1 [endoplasmic reticulum membrane] (Bos taurus)

SGPL1 [endoplasmic reticulum membrane] (Sus scrofa)

Sply [endoplasmic reticulum membrane] (Drosophila melanogaster)

sgpl1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Sgpl1 [endoplasmic reticulum membrane] (Mus musculus)

Sgpl1 [endoplasmic reticulum membrane] (Rattus norvegicus)

sglA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

zgc:162153 [endoplasmic reticulum membrane] (Danio rerio)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 353

Coordinate

353

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

XP_011538619.1, NP_003892.2, XP_005270320.1, XP_011538618.1

Guide to Pharmacology - Targets

2522

OpenTargets

ENSG00000166224

ZINC - Substances

SGPL1_HUMAN

ZINC target

O95470

PRO

O95470

PDB

4Q6R

IntEnz

4.1.2.27

HPA

ENSG00000166224-SGPL1

GeneCards

O95470

Ensembl

ENSG00000166224, ENSP00000513482, ENST00000373202, ENST00000697928, ENSP00000513485, ENSP00000362298, ENST00000697931, ENSP00000513486, ENST00000697932

Pharos - Targets

O95470

Orphanet

25622

ZINC - Predictions - Purchasable

SGPL1_HUMAN

HMDB Protein

HMDBP01052

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NX47 MARH5			0.556	3
UniProt:Q8TAC9 SCAM5			0.556	3
UniProt:Q8NHW4 CCL4L1	1	CCL4L1 [extracellular region] (R-HSA-8865389)	0.556	3
UniProt:Q96HP8 T176A			0.556	3
UniProt:Q04941 PLP2			0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:Q92482 AQP3	1	AQP3 [plasma membrane] (R-HSA-431723)	0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.556	3
UniProt:Q5GAN6 RNS10			0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:Q92843 B2CL2			0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:O14817 TSN4			0.556	3
UniProt:Q9UKR5 ERG28			0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q5BJF2 SGMR2			0.556	3
UniProt:Q6PL45-2 BRICD5			0.556	3
UniProt:Q99726 SLC30A3	1	SLC30A3 [synaptic vesicle membrane] (R-HSA-437087)	0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.556	3
UniProt:P02808 STAT			0.556	3
UniProt:Q9NWH2 TM242			0.556	3
UniProt:Q5VZY2 PLPP4	1	PPAPDC1A [plasma membrane] (R-HSA-2029082)	0.556	3
UniProt:P30301 MIP	1	MIP [plasma membrane] (R-HSA-432026)	0.556	3
UniProt:P52803 EFNA5	3	EFNA5 (21-?) N-ter [extracellular region] (R-HSA-3928456) EFNA5 (?-203) C-ter [plasma membrane] (R-HSA-3928431) EFNA5 [plasma membrane] (R-HSA-2682331)	0.556	3
UniProt:Q9UNK0 STX8			0.556	3
UniProt:Q8N128-2 FAM177A1			0.556	3
UniProt:Q6ZSS7 MFSD6			0.556	3
UniProt:Q9NXK6 PAQR5			0.556	3
UniProt:Q8IY49-2 MMD2			0.556	3
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q8N6F1-2 CLDN19			0.556	3
UniProt:Q86WV6 STING1	5	TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.499	2

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