Reactome | GNB4 [plasma membrane]

GNB4 [plasma membrane]

Stable Identifier

R-HSA-164326

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein beta 4 (GBB4) subunit

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein activation (Homo sapiens)
        
        The receptor:G-protein complex binds GTP (Homo sapiens)
        
        Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
        
        G-protein beta subunit [plasma membrane] (Homo sapiens)
        
        GNB4 [plasma membrane] (Homo sapiens)
        
        The receptor:G-protein complex releases GDP (Homo sapiens)
        
        Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
        
        G-protein beta subunit [plasma membrane] (Homo sapiens)
        
        GNB4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HAV0 GNB4

Gene Names

GNB4

Chain

initiator methionine:, chain:2-340

Reference Genes

BioGPS Gene:59345 GNB4

COSMIC (genes):GNB4 GNB4

CTD Gene:59345 GNB4

dbSNP Gene:59345 GNB4

ENSEMBL:ENSG00000114450 GNB4

HGNC:20731 GNB4

KEGG:hsa:59345 GNB4

Monarch:59345 GNB4

NCBI Gene:59345 GNB4

OMIM:610863 GNB4

UCSC:Q9HAV0 GNB4

Reference Transcript

Other Identifiers

11723102_at

11723103_x_at

11723104_at

11751252_a_at

16961806

223487_3p_x_at

223487_PM_x_at

223487_x_at

223488_PM_s_at

223488_s_at

225710_PM_at

225710_at

2706935

2706937

2706939

2706940

2706941

2706942

2706943

2706945

2706946

2706947

2706949

2706950

2706951

2706952

2706954

2706955

2706960

2706961

2706962

2706963

2706964

2706969

54807_at

59345

62744_at

8092251

A_23_P18186

A_32_P171313

A_32_P184916

GE501776

GE62852

GO:0005515

GO:0005737

GO:0005765

GO:0005829

GO:0005834

GO:0007165

GO:0007186

GO:0021762

GO:0030159

GO:0043226

GO:0044297

GO:0044877

GO:0045202

GO:0048856

GO:0060090

GO:0070062

HMNXSV003022963

HMNXSV003040417

Hs.172654.0.S2_3p_at

Hs.173030.0.A1_3p_at

ILMN_1733249

ILMN_2129545

PH_hs_0010369

PH_hs_0027647

TC03002038.hg

g12654118_3p_a_at

Participates

as a candidate of

G-protein beta subunit [plasma membrane] (Homo sapiens)

Other forms of this molecule

Partially folded GNB4 [cytosol]

Unfolded GNB4 [cytosol]

GNB4 [cytosol]

Inferred To

Gbeta13F [plasma membrane] (Drosophila melanogaster)

GNB4 [plasma membrane] (Bos taurus)

GNB4 [plasma membrane] (Canis familiaris)

GNB4 [plasma membrane] (Gallus gallus)

GNB4 [plasma membrane] (Sus scrofa)

gnb4 [plasma membrane] (Xenopus tropicalis)

gpb-1 [plasma membrane] (Caenorhabditis elegans)

Gbeta76C [plasma membrane] (Drosophila melanogaster)

Gnb4 [plasma membrane] (Mus musculus)

Gnb4 [plasma membrane] (Rattus norvegicus)

Homologues of GNB1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_067642.1, XP_006713784.1, XP_005247749.1

ENSEMBL

ENSP00000501882, ENST00000232564, ENST00000676128, ENSP00000232564, ENSG00000114450, ENST00000674862, ENSP00000502628

OpenTargets

ENSG00000114450

GeneCards

GNB4

HPA

ENSG00000114450-GNB4

PRO

Q9HAV0

Pharos - Targets

Q9HAV0

GlyGen

Q9HAV0

Orphanet

GNB4

HMDB Protein

HMDBP08401

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) SDC1 [Golgi lumen] (R-HSA-2054105) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349) Heparan-SDC1 [Golgi lumen] (R-HSA-2076561)	0.527	2

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