Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-S207,T211-MAP2K6 [cytosol]
Stable Identifier
R-SSC-206255
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
A0A5K1UKA4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular Senescence (Sus scrofa)
Oxidative Stress Induced Senescence (Sus scrofa)
MAP3K5 phosphorylates MKK3 and MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Antimicrobial mechanism of IFN-stimulated genes (Sus scrofa)
PKR-mediated signaling (Sus scrofa)
p-PKR dimer phosphorylates MKK6 (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
TAK1 phosphorylates MKK6 (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Interleukin-17 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Sus scrofa)
NOD1/2 Signaling Pathway (Sus scrofa)
Activation of p38 MAPK (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
TAK1 phosphorylates MKK6 (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
MAP kinase activation (Sus scrofa)
activated TAK1 mediates p38 MAPK activation (Sus scrofa)
Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A5K1UKA4
Reference Genes
BioGPS Gene:100625946
ENSEMBL:ENSSSCG00000017254.6
KEGG:ssc:100625946
Monarch:100625946
NCBI Gene:100625946
UCSC:A0A5K1UKA4
Reference Transcript
RefSeq:XM_013980816.2
Other Identifiers
100625946
GO:0000165
GO:0000166
GO:0001649
GO:0003012
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0005524
GO:0005654
GO:0005829
GO:0006468
GO:0006954
GO:0016301
GO:0016740
GO:0019901
GO:0030154
GO:0031098
GO:0038066
GO:0043410
GO:0048856
GO:0051403
GO:0051604
GO:0060048
GO:0060348
GO:0065003
GO:0070269
GO:0071493
GO:0120163
GO:0140096
GO:1902531
GO:1904784
Ssc.13711.1.S1_at
Ssc.27058.1.A1_at
Ssc.30980.1.A1_at
Participates
as an output of
p-PKR dimer phosphorylates MKK6 (Sus scrofa)
TAK1 phosphorylates MKK6 (Sus scrofa)
as a member of
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)
Other forms of this molecule
MAP2K6 [cytosol]
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
Inferred From
p-S207,T211-MAP2K6 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 207 (in Homo sapiens)
Coordinate
207
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 211 (in Homo sapiens)
Coordinate
211
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_013836270.1
ENSEMBL
ENSSSCP00000030562
,
ENSSSCG00000017254
,
ENSSSCT00000035633
VGNC
98102
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text