TAK1 phosphorylates MKK6

Stable Identifier
R-HSA-727819
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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TAK1 phosphorylates MKK6
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Within the TAK1 complex (TAK1 plus TAB1 and TAB2/3) activated TAK1 phosphorylates IKKB, MAPK kinase 6 (MKK6) and other MAPKs to activate the NFkappaB and MAPK signaling pathways. TAB2 within the TAK1 complex can be linked to polyubiquitinated TRAF6; current models of IL-1 signaling suggest that the TAK1 complex is linked to TRAF6, itself complexed with polyubiquitinated IRAK1 which is linked via NEMO to the IKK complex. The TAK1 complex is also essential for NOD signaling; NOD receptors bind RIP2 which recruits the TAK1 complex (Hasegawa et al. 2008).

Literature References
PubMed ID Title Journal Year
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C, Deng, L, Hong, M, Akkaraju, GR, Inoue, J, Chen, ZJ

Nature 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
MAP kinase kinase kinase activity of TAK1 complex [cytosol]
Physical Entity
TAK1 complex [cytosol]
Activity
MAP kinase kinase kinase activity (0004709)
Orthologous Events
TAK1 phosphorylates MKK6 (Bos taurus)
TAK1 phosphorylates MKK6 (Canis familiaris)
TAK1 phosphorylates MKK6 (Danio rerio)
TAK1 phosphorylates MKK6 (Gallus gallus)
TAK1 phosphorylates MKK6 (Mus musculus)
TAK1 phosphorylates MKK6 (Rattus norvegicus)
TAK1 phosphorylates MKK6 (Sus scrofa)
TAK1 phosphorylates MKK6 (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-05-12)