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phospho-MAP2K6 [cytosol]
Stable Identifier
R-CFA-206255
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S207,T211-MAP2K6, A0A8I3NBF5
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
Oxidative Stress Induced Senescence (Canis familiaris)
MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antimicrobial mechanism of IFN-stimulated genes (Canis familiaris)
PKR-mediated signaling (Canis familiaris)
p-PKR dimer phosphorylates MKK6 (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1 phosphorylates MKK6 (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
Activation of p38 MAPK (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
TAK1 phosphorylates MKK6 (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NBF5
Gene Names
MAP2K6
Reference Genes
BioGPS Gene:480454 MAP2K6
ENSEMBL:ENSCAFG00845005385.1
KEGG:cfa:480454 MAP2K6
Monarch:480454 MAP2K6
NCBI Gene:480454 MAP2K6
UCSC:A0A8I3NBF5 MAP2K6
Reference Transcript
RefSeq:XM_038546743.1 MAP2K6
RefSeq:XM_038676131.1 MAP2K6
RefSeq:XM_005624291.3 MAP2K6
RefSeq:XM_845930.6 MAP2K6
RefSeq:XM_038676130.1 MAP2K6
RefSeq:XM_038546742.1 MAP2K6
Other Identifiers
480454
Cfa.13636.1.A1_at
Cfa.13636.1.A1_s_at
CfaAffx.16824.1.S1_at
GO:0000165
GO:0000166
GO:0001649
GO:0003012
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0005524
GO:0005654
GO:0005829
GO:0006468
GO:0006954
GO:0016301
GO:0016740
GO:0019901
GO:0030154
GO:0031098
GO:0038066
GO:0043410
GO:0048856
GO:0051403
GO:0051604
GO:0060048
GO:0060348
GO:0065003
GO:0070269
GO:0071493
GO:0120163
GO:0140096
GO:1902531
GO:1904784
Participates
as an output of
p-PKR dimer phosphorylates MKK6 (Canis familiaris)
TAK1 phosphorylates MKK6 (Canis familiaris)
as a member of
p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)
Other forms of this molecule
MAP2K6 [cytosol]
phospho-MAP2K6 [nucleoplasm]
Inferred From
p-S207,T211-MAP2K6 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 207 (in Homo sapiens)
Coordinate
207
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 211 (in Homo sapiens)
Coordinate
211
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_038532058.1
,
XP_851023.1
,
XP_005624348.3
,
XP_038402670.1
,
XP_038402671.1
,
XP_038532059.1
ENSEMBL
ENSCAFT00845009565
,
ENSCAFG00845005385
,
ENSCAFP00845007481
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