Reactome | p-PKR dimer phosphorylates MKK6

p-PKR dimer phosphorylates MKK6

Stable Identifier

R-HSA-9836322

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation of dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6, MKK6), an essential component of the MAP kinase signal transduction pathway, by Protein kinase R (PKR, EIF2AK2) is required for p38 activation. Activated PKR modifies MKK6 at residues S207 and T211 (Goh et al, 2000; Silva et al, 2004). The current knowledge of involvement of PKR in neurodegenerative diseases was reviewed by Hugon & Paquet, 2021.

Literature References

PubMed ID	Title	Journal	Year
33808629	The PKR/P38/RIPK1 Signaling Pathway as a Therapeutic Target in Alzheimer's Disease Hugon, J, Paquet, C	Int J Mol Sci	2021
15229216	Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation Silva, AM, Li, X, Whitmore, M, Jiang, Z, Williams, BR, Xu, Z	J Biol Chem	2004