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PHF8 [nucleoplasm]
Stable Identifier
R-HSA-5423096
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone lysine demethylase PHF8, PHF8_HUMAN, JHDM1E
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Homo sapiens)
KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8 [nucleoplasm] (Homo sapiens)
PHF8 [nucleoplasm] (Homo sapiens)
KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)
KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8 [nucleoplasm] (Homo sapiens)
PHF8 [nucleoplasm] (Homo sapiens)
PHF8 demethylates MeK21-histone H4 (Homo sapiens)
PHF8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPP1 PHF8
Gene Names
PHF8, KIAA1111, ZNF422
Chain
chain:1-1060
Reference Genes
BioGPS Gene:23133 PHF8
COSMIC (genes):PHF8 PHF8
CTD Gene:23133 PHF8
dbSNP Gene:23133 PHF8
ENSEMBL:ENSG00000172943 PHF8
ENSEMBL_homo_sapiens_GENE:ENSG00000172943.21 PHF8
HGNC:20672 PHF8
KEGG Gene (Homo sapiens):23133 PHF8
Monarch:23133 PHF8
NCBI Gene:23133 PHF8
OMIM:300560 PHF8
UCSC:Q9UPP1 PHF8
Reference Transcript
RefSeq:XM_017029362.1 PHF8
RefSeq:NM_001184897.1 PHF8
RefSeq:NM_001184896.1 PHF8
RefSeq:NM_015107.2 PHF8
Other Identifiers
11719423_at
11756084_a_at
17111366
212916_PM_at
212916_at
23133
4009503
4009505
4009507
4009508
4009509
4009510
4009511
4009512
4009513
4009516
4009521
4009522
4009524
4009526
4009527
4009528
4009530
4009531
4009532
4009534
4009536
4009538
4009539
4009540
4009542
4009543
4009544
4009545
4009546
4009547
4009549
4009550
4009552
4009553
4009554
4009555
41399_at
8173009
A_23_P9744
A_24_P130865
A_24_P942253
A_33_P3361925
GO:0000082
GO:0000278
GO:0003682
GO:0003712
GO:0003824
GO:0005506
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005730
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0007049
GO:0007420
GO:0008270
GO:0016491
GO:0016706
GO:0031965
GO:0032452
GO:0032454
GO:0035064
GO:0035575
GO:0036211
GO:0042393
GO:0043226
GO:0045893
GO:0045943
GO:0045944
GO:0046872
GO:0048856
GO:0051213
GO:0051864
GO:0061188
GO:0071558
GO:0140096
GO:0140110
GO:0140680
GO:0140683
GO:0141052
HMNXSV003015923
HMNXSV003018229
HMNXSV003026449
Hs.285641.0.S1_3p_at
ILMN_1711318
ILMN_2230530
PH_hs_0022505
TC0X001070.hg
Participates
as a member of
KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8 [nucleoplasm] (Homo sapiens)
Inferred To
Phf8 [nucleoplasm]
(Rattus norvegicus)
PHF8-1 [nucleoplasm]
(Caenorhabditis elegans)
PHF8-1 [nucleoplasm]
(Danio rerio)
PHF8-1 [nucleoplasm]
(Schizosaccharomyces pombe)
PHF8 [nucleoplasm]
(Bos taurus)
PHF8 [nucleoplasm]
(Canis familiaris)
PHF8 [nucleoplasm]
(Mus musculus)
PHF8 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001171826.1
,
NP_055922.1
,
XP_016884851.1
,
NP_001171825.1
Guide to Pharmacology - Targets
2698
OpenTargets
ENSG00000172943
ZINC - Substances
PHF8_HUMAN
ZINC target
Q9UPP1
ZINC - Biogenic
PHF8_HUMAN
PRO
Q9UPP1
PDB
4DO0
,
7CMZ
,
3KV4
,
3K3O
,
2WWU
,
3K3N
ZINC - Metabolites
PHF8_HUMAN
GeneCards
Q9UPP1
HPA
ENSG00000172943-PHF8
Ensembl
ENST00000322659
,
ENSP00000350676
,
ENSP00000338868
,
ENST00000357988
,
ENSP00000319473
,
ENSG00000172943
,
ENST00000338154
Pharos - Targets
Q9UPP1
ZINC - Predictions - Purchasable
PHF8_HUMAN
Orphanet
16818
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y462 ZNF711
1
ZNF711 [nucleoplasm]
(R-HSA-2454159)
0.69
7
UniProt:Q16778 H2BC21
9
Ub-HIST2H2BE [nucleoplasm]
(R-HSA-6782539)
Ack-HIST2H2BE [nucleoplasm]
(R-HSA-4549257)
HIST2H2BE [extracellular region]
(R-HSA-977571)
AcK13-HIST2H2BE [nucleoplasm]
(R-HSA-4568651)
AcK21-HIST2H2BE [nucleoplasm]
(R-HSA-4568716)
AcK6-HIST2H2BE [nucleoplasm]
(R-HSA-4568679)
AcK16-HIST2H2BE [nucleoplasm]
(R-HSA-4568660)
Ub-121-HIST2H2BE [nucleoplasm]
(R-HSA-3364018)
HIST2H2BE [nucleoplasm]
(R-HSA-181908)
0.527
2
UniProt:Q96QS3 ARX
0.524
3
UniProt:Q06330 RBPJ
1
RBPJ [nucleoplasm]
(R-HSA-3008668)
0.499
2
UniProt:Q01094 E2F1
2
E2F1 [nucleoplasm]
(R-HSA-68639)
p-E2F1 [nucleoplasm]
(R-HSA-187911)
0.499
2
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
7
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