Reactome | KAT2B [nucleoplasm]

KAT2B [nucleoplasm]

Stable Identifier

R-HSA-352430

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PCAF, PCAF_HUMAN, Histone acetyltransferase PCAF

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Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - KAT2 complexes acetylate histone H3 (Homo sapiens)
      - KAT2A,B complexes [nucleoplasm] (Homo sapiens)
        
        ATAC complex [nucleoplasm] (Homo sapiens)
        
        KAT2A,B [nucleoplasm] (Homo sapiens)
        
        KAT2B [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Metalloprotease DUBs (Homo sapiens)
      - MYSM1 deubiquitinates Histone H2A (Homo sapiens)
        
        MYSM1:EP300:KAT2B:Histone H2A [nucleoplasm] (Homo sapiens)
        
        MYSM1:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        KAT2B [nucleoplasm] (Homo sapiens)
        
        MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm] (Homo sapiens)
        
        MYSM1:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        KAT2B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92831 KAT2B

Gene Names

KAT2B, PCAF

Chain

chain:1-832

Reference Genes

BioGPS Gene:8850 KAT2B

COSMIC (genes):KAT2B KAT2B

CTD Gene:8850 KAT2B

dbSNP Gene:8850 KAT2B

ENSEMBL:ENSG00000114166 KAT2B

HGNC:8638 KAT2B

KEGG:hsa:8850 KAT2B

Monarch:8850 KAT2B

NCBI Gene:8850 KAT2B

OMIM:602303 KAT2B

UCSC:Q92831 KAT2B

Reference Transcript

RefSeq:NM_003884.4 KAT2B

Other Identifiers

1012_at

11720667_a_at

11720668_at

11720669_at

16938271

203845_PM_at

203845_at

239585_PM_at

239585_at

2613443

2613453

2613464

2613465

2613466

2613468

2613469

2613471

2613473

2613474

2613476

2613477

2613480

2613481

2613485

2613487

2613488

2613489

2613490

2613491

2613492

2613493

2613495

2613496

63536_at

63537_g_at

63868_at

69300_at

70152_r_at

8078227

8850

A_23_P41128

A_32_P159651

GE81332

GO:0000122

GO:0000123

GO:0000124

GO:0000432

GO:0000776

GO:0000785

GO:0000977

GO:0003013

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003824

GO:0004145

GO:0004402

GO:0004468

GO:0004861

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005975

GO:0006094

GO:0006282

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0006473

GO:0007507

GO:0007613

GO:0008285

GO:0010468

GO:0010484

GO:0010835

GO:0010976

GO:0016407

GO:0016740

GO:0016746

GO:0016747

GO:0018076

GO:0018393

GO:0018394

GO:0019901

GO:0031672

GO:0031674

GO:0032869

GO:0032991

GO:0034599

GO:0035035

GO:0042311

GO:0042641

GO:0042826

GO:0043226

GO:0043484

GO:0043992

GO:0045722

GO:0045723

GO:0045815

GO:0045821

GO:0045893

GO:0045944

GO:0045995

GO:0046600

GO:0046889

GO:0048511

GO:0048856

GO:0050877

GO:0051302

GO:0051604

GO:0051726

GO:0060090

GO:0060173

GO:0061733

GO:0071374

GO:0072686

GO:0090043

GO:0098772

GO:0140096

GO:0140110

GO:0140297

GO:0140672

GO:1902425

GO:2000233

HMNXSV003039099

HMNXSV003042458

HMNXSV003044840

Hs.199061.0.A2_3p_at

Hs.203475.0.A1_3p_at

ILMN_1733802

ILMN_1892184

PH_hs_0023017

TC03000113.hg

U57317_at

Participates

as a member of

as a component of

as an input of

Inferred To

Gcn5 [nucleoplasm] (Drosophila melanogaster)

pcaf-1 [nucleoplasm] (Caenorhabditis elegans)

gcn5 [nucleoplasm] (Dictyostelium discoideum)

KAT2B [nucleoplasm] (Bos taurus)

KAT2B [nucleoplasm] (Canis familiaris)

KAT2B [nucleoplasm] (Danio rerio)

KAT2B [nucleoplasm] (Gallus gallus)

KAT2B [nucleoplasm] (Mus musculus)

KAT2B [nucleoplasm] (Plasmodium falciparum)

KAT2B [nucleoplasm] (Rattus norvegicus)

KAT2B [nucleoplasm] (Saccharomyces cerevisiae)

KAT2B [nucleoplasm] (Schizosaccharomyces pombe)

KAT2B [nucleoplasm] (Sus scrofa)

KAT2B [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003875.3

Guide to Pharmacology - Targets

2737

OpenTargets

ENSG00000114166

ENSEMBL

ENSP00000263754, ENST00000263754, ENSG00000114166

ZINC - Substances

KAT2B_HUMAN

ZINC - Biogenic

KAT2B_HUMAN

ZINC target

Q92831

PRO

Q92831

PDB

5FDZ, 1ZS5, 5FE3, 6J3O, 5FE2, 5FE9, 5FE8, 1WUG, 1WUM, 1N72, 1CM0, 1JM4, 4NSQ, 3GG3, 5FE1, 5FE0, 5FE7, 5FE6, 5FE4, 5FE5, 5LVQ, 5LVR, 5MKX, 2RNW, 2RNX

ZINC - Investigational

KAT2B_HUMAN

ZINC - Metabolites

KAT2B_HUMAN

HPA

ENSG00000114166-KAT2B

GeneCards

KAT2B

Pharos - Targets

Q92831

ZINC - Predictions - Purchasable

KAT2B_HUMAN

HMDB Protein

HMDBP00027

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.725	4
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.715	14
UniProt:P03129 VE7			0.698	5
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.656	4
UniProt:P03255-2			0.656	3
UniProt:Q9Y6J9 TAF6L	1	TAF6L [nucleoplasm] (R-HSA-212393)	0.643	3
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.643	5
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.643	3
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.623	5
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.615	3
UniProt:P84040	14	His4:CG33889 [nucleoplasm] (R-DME-181902) His4:CG33889 [nucleoplasm] (R-DME-5651652) His4:CG33889 [nucleoplasm] (R-DME-3451124) His4:CG33889 [nucleoplasm] (R-DME-5423110) His4:CG33889 [nucleoplasm] (R-DME-4568758) His4:CG33889 [nucleoplasm] (R-DME-4568748) His4:CG33889 [nucleoplasm] (R-DME-427469) His4:CG33889 [nucleoplasm] (R-DME-5651656) His4:CG33889 [nucleoplasm] (R-DME-4754240) His4:CG33889 [nucleoplasm] (R-DME-4754243) His4:CG33889 [nucleoplasm] (R-DME-5229015) His4:CG33889 [nucleoplasm] (R-DME-4568744) His4:CG33889 [nucleoplasm] (R-DME-212078) His4:CG33889 [nucleoplasm] (R-DME-4570531)	0.609	2
UniProt:P02299	20	His3:CG33845 [nucleoplasm] (R-DME-212281) His3:CG33845 [nucleoplasm] (R-DME-1214225) His3:CG33845 [nucleoplasm] (R-DME-212253) His3:CG33845 [nucleoplasm] (R-DME-1214223) His3:CG33845 [nucleoplasm] (R-DME-427744) phospho-His3:CG33845 [nucleoplasm] (R-DME-5625754) phospho-His3:CG33845 [nucleoplasm] (R-DME-5625792) phospho-His3:CG33845 [nucleoplasm] (R-DME-5625857) phospho-His3:CG33845 [nucleoplasm] (R-DME-5625871) His3:CG33845 [nucleoplasm] (R-DME-4568752) His3:CG33845 [nucleoplasm] (R-DME-4568750) His3:CG33845 [nucleoplasm] (R-DME-4549224) His3:CG33845 [nucleoplasm] (R-DME-4568747) His3:CG33845 [nucleoplasm] (R-DME-427407) His3:CG33845 [nucleoplasm] (R-DME-4568924) His3:CG33845 [nucleoplasm] (R-DME-8936570) His3:CG33845 [nucleoplasm] (R-DME-417240) phospho-His3:CG33845 [nucleoplasm] (R-DME-8871289) phospho-His3:CG33845 [nucleoplasm] (R-DME-8871302) phospho-His3:CG33845 [nucleoplasm] (R-DME-8871290)	0.609	2
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.576	4
UniProt:P28033 Cebpb	4	Cebpb [nucleoplasm] (R-MMU-442471) Cebpb [nucleoplasm] (R-MMU-381378) phospho-Cebpb [nucleoplasm] (R-MMU-3857343) phospho-Cebpb [nucleoplasm] (R-MMU-3857339)	0.558	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P06790 VE2			0.544	4
UniProt:Q9Y5W3 KLF2			0.544	2
UniProt:Q16514 TAF12	1	TAF12 [nucleoplasm] (R-HSA-65555)	0.527	2
UniProt:Q96BN2 TADA1	1	TADA1 [nucleoplasm] (R-HSA-3322965)	0.527	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.527	2
UniProt:O75486 SUPT3H	1	SUPT3H [nucleoplasm] (R-HSA-3322944)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:Q12962 TAF10	1	TAF10 [nucleoplasm] (R-HSA-65551)	0.527	3
UniProt:P43363 MAGAA			0.527	2
UniProt:Q14CW9 ATXN7L3	1	ATXN7L3 [nucleoplasm] (R-HSA-3662285)	0.527	2
UniProt:Q9H5V7 IKZF5			0.527	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.525	3
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.524	2
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.524	3
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131)	0.524	2
UniProt:P03255 E1A			0.508	3
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.499	2
UniProt:Q16594 TAF9	1	TAF9 [nucleoplasm] (R-HSA-212452)	0.499	3

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