Reactome | Elob [cytosol]

Elob [cytosol]

Stable Identifier

R-MMU-9707901

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Elongin-B, ELOB_MOUSE

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to hypoxia (Mus musculus)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Mus musculus)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
      - Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
        
        VBC complex (with or without LIMD1) [cytosol] (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Mus musculus)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
        
        VBC complex [cytosol] (Mus musculus)
        
        Elob [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P62869 Elob

Gene Names

Elob, Tceb2

Chain

chain:1-118

Reference Genes

BioGPS Gene:67673 Elob

KEGG:mmu:67673 Elob

Monarch:67673 Elob

NCBI Gene:67673 Elob

UCSC:P62869 Elob

Reference Transcript

RefSeq:NM_026305.2 Elob

Other Identifiers

10448380

10452890

108083_at

1428263_a_at

1436949_a_at

160402_at

17341625

17547811

4309837

4432157

4547800

4563702

4597420

4670536

4682381

4848334

4988133

4991178

5041958

5063592

5167233

5332296

5399159

5584448

67673

A_51_P397823

A_66_P138780

GE41184

GO:0001222

GO:0003713

GO:0005515

GO:0005634

GO:0005667

GO:0005829

GO:0006355

GO:0006367

GO:0006368

GO:0016567

GO:0030891

GO:0031047

GO:0031462

GO:0031466

GO:0031625

GO:0043226

GO:0044877

GO:0045893

GO:0060090

GO:0070449

GO:0140110

GO:0140958

ILMN_1216504

ILMN_2658574

ILMN_2687706

ILMN_2744326

mMC006697

mMC023876

mMR030533

Participates

as an output of

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)

as a component of

as an input of

Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7 (Mus musculus)

Other forms of this molecule

Elob [nucleoplasm]

Inferred From

ELOB [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSP00000066210, ENSMUST00000069579, ENSMUSG00000055839

PRO

P62869

MGI

1914923

PDB

4JGH, 2FNJ

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