Reactome | p-5Y-RET complexes bind GRB2

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p-5Y-RET complexes bind GRB2 Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10076408
displayName	p-5Y-RET complexes bind GRB2
eventOf	[Pathway:R-MMU-8853659] RET signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-74686] Grb2 [cytosol] [DefinedSet:R-MMU-8854900] p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-5Y-RET complexes bind GRB2
output	[DefinedSet:R-MMU-8854907] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-MMU-8854981] SHC1 in the RET complex is phosphorylated - Mus musculus [Reaction:R-MMU-8853792] RET tyrosine phosphorylation - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-8853793
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8853659] RET signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2
(inferredTo)	[BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2