Reactome | IRS1 recruits GRB2 to active LTK

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10094605
displayName	IRS1 recruits GRB2 to active LTK
eventOf	[Pathway:R-MMU-9842663] Signaling by LTK - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9842655] IRS1 recruits GRB2 to active LTK - Homo sapiens
input	[Complex:R-MMU-9842601] Active LTK:p-Y IRS1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-74686] Grb2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IRS1 recruits GRB2 to active LTK
output	[Complex:R-MMU-9842595] Active LTK:p-Y IRS1:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-9842666] Active LTK phosphorylates IRS1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9842655
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-9842663] Signaling by LTK
(inferredTo)	[Reaction:R-HSA-9842655] IRS1 recruits GRB2 to active LTK

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