Reactome | GRB2:GAB1 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Mus musculus [Complex:R-MMU-180282] GRB2:GAB1:PIP3 [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - Mus musculus [Reaction:R-MMU-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Mus musculus [Reaction:R-MMU-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9999614
displayName	GRB2:GAB1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-MMU-179795] Gab1 [cytosol] [EntityWithAccessionedSequence:R-MMU-74686] Grb2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-179849] GRB2:GAB1 [cytosol] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-MMU-9038397] GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] - Mus musculus
name	GRB2:GAB1
producedByEvent	[Reaction:R-MMU-177920] Binding of GRB2 to GAB1 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-179849
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-MMU-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR [Reaction:R-MMU-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate [Reaction:R-MMU-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
(hasMember)	[DefinedSet:R-MMU-9038397] GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol]
(hasComponent)	[Complex:R-MMU-180282] GRB2:GAB1:PIP3 [plasma membrane] [Complex:R-MMU-179864] GRB2:GAB1:PIK3R1 [cytosol] [Complex:R-MMU-9028508] BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] [Complex:R-MMU-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(output)	[Reaction:R-MMU-177920] Binding of GRB2 to GAB1
(inferredTo)	[Complex:R-HSA-179849] GRB2:GAB1 [cytosol]