Reactome | Activated MET binds GAB1 and GRB2

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Activated MET binds GAB1 and GRB2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10075862
displayName	Activated MET binds GAB1 and GRB2
eventOf	[Pathway:R-MMU-8851907] MET activates PI3K/AKT signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8851933] MET phosphorylates GAB1 - Mus musculus
inferredFrom	[Reaction:R-HSA-8851919] Activated MET binds GAB1 and GRB2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-179795] Gab1 [cytosol] [EntityWithAccessionedSequence:R-MMU-74686] Grb2 [cytosol] [Complex:R-MMU-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated MET binds GAB1 and GRB2
output	[Complex:R-MMU-8851921] HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-6806974] MET dimers autophosphorylate - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8851919
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8851907] MET activates PI3K/AKT signaling
(precedingEvent)	[Reaction:R-MMU-8851933] MET phosphorylates GAB1
(inferredTo)	[Reaction:R-HSA-8851919] Activated MET binds GAB1 and GRB2

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