Reactome | Interaction of Tie2 and Grb2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10005706
displayName	Interaction of Tie2 and Grb2
eventOf	[Pathway:R-MMU-210993] Tie2 Signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Mus musculus
inferredFrom	[Reaction:R-HSA-204871] Interaction of Tie2 and Grb2 - Homo sapiens
input	[Complex:R-MMU-204783] ANGPT1:p-5Y,S119-TEK [plasma membrane] [EntityWithAccessionedSequence:R-MMU-74686] Grb2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of Tie2 and Grb2
output	[Complex:R-MMU-204865] Grb2 bound to Tie2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-204871
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-210993] Tie2 Signaling
(precedingEvent)	[Reaction:R-MMU-210974] Interaction of SOS-1 to Tie2 bound Grb2
(inferredTo)	[Reaction:R-HSA-204871] Interaction of Tie2 and Grb2

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