Reactome | Negative Regulation of CDH1 Gene Transcription

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Negative Regulation of CDH1 Gene Transcription Show undefined attributes

authored	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
created	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
dbId	9764725
displayName	Negative Regulation of CDH1 Gene Transcription
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9764560] Regulation of CDH1 Gene Transcription - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9768477] CTBP1,CTBP2 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9768511] CTBP1,CTBP2 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9764811] DNTTIP1 binds CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9764826] DNTTIP1 recruits KDM1A to CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9764827] DNTTIP1 and KDM1A repress CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9768082] FOXQ1 bind CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9768079] FOXQ1 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9764930] PRC2 (EZH2) core complex binds CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9764932] PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9764934] PRC2 (EZH2) mediates repression of CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9756414] SNAI1 binds the CDH1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9764752] SNAI1 represses CDH1 transcription - Homo sapiens [Reaction:R-HSA-9768533] SNAI2 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9768484] SNAI2 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9765742] TCF3 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9765756] TCF3 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9767922] TCF12 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9767924] TCF12 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9766062] PKM and TGIF2 bind CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9766065] PKM and TGIF2 repress CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9765015] TWIST1 binds CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9765788] TWIST1 recruits SETD8 to CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9765049] TWIST1 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9765169] TWIST2 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9765175] TWIST2 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9767700] WT1 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9767706] WT1 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9767787] ZBTB33 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9767779] ZBTB33 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9764741] ZEB1 binds CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9764786] ZEB1 recruits SMARCA4 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9765791] ZEB1 recruits SETD8 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9764778] ZEB1 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9765973] CTBP1,CTBP2 binds ZEB1 - Homo sapiens [Reaction:R-HSA-9765974] MCRIP1 binds CTBP1 - Homo sapiens [Reaction:R-HSA-9765960] ERKs phosphorylate MCRIP1 - Homo sapiens [Reaction:R-HSA-9765313] ZEB2 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9765293] ZEB2 represses CDH1 gene transcription - Homo sapiens [Reaction:R-HSA-9768067] ZNF217 binds CDH1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9768071] ZNF217 represses CDH1 gene transcription - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9765135] Twist: a molecular target in cancer therapeutics [LiteratureReference:9765764] Hepatitis C virus core protein interacts with Snail and histone deacetylases to promote the metastasis of hepatocellular carcinoma [LiteratureReference:9765784] Grhl3 induces human epithelial tumor cell migration and invasion via downregulation of E-cadherin [LiteratureReference:9765182] Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications [LiteratureReference:9765827] G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation [LiteratureReference:9765891] LIGHT is a crucial mediator of airway remodeling [LiteratureReference:9766454] The effects of shRNA-mediated gene silencing of transcription factor SNAI1 on the biological phenotypes of breast cancer cell line MCF-7 [LiteratureReference:9766453] Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition [LiteratureReference:9767568] Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells [LiteratureReference:9767574] Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer [LiteratureReference:9767565] Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer [LiteratureReference:9767719] E47 and Id1 interplay in epithelial-mesenchymal transition [LiteratureReference:9767714] Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion [LiteratureReference:9767854] Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer [LiteratureReference:9768111] IKK(?) controls canonical TGF(�)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells [LiteratureReference:9768189] 14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation [LiteratureReference:9756426] A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition [LiteratureReference:9768259] Tbx3 represses E-cadherin expression and enhances melanoma invasiveness [LiteratureReference:9768257] Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor [LiteratureReference:9768391] Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1 [LiteratureReference:9768507] Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition [LiteratureReference:9768550] Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells [LiteratureReference:9768546] Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer [LiteratureReference:9768450] Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex [LiteratureReference:9768496] Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions [LiteratureReference:9756447] The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells [LiteratureReference:9756421] The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [LiteratureReference:9767843] Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer [LiteratureReference:9767702] The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells [LiteratureReference:9768255] Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3 [LiteratureReference:9931357] Secreted heat shock protein 90? (HSP90?) induces nuclear factor-?B-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion [LiteratureReference:9931136] Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence [LiteratureReference:9931744] Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer [LiteratureReference:9765342] ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat-Wilson syndrome [LiteratureReference:9768562] The SLUG zinc-finger protein represses E-cadherin in breast cancer [LiteratureReference:9766058] Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition [LiteratureReference:9765479] SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer [LiteratureReference:9931215] Wilms' tumor 1 (WT1) promotes ovarian cancer progression by regulating E-cadherin and ERK1/2 signaling [LiteratureReference:9857452] Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug [LiteratureReference:9815740] The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer [LiteratureReference:9765789] SET8 induces epithelial?mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 [LiteratureReference:9764838] MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail [LiteratureReference:9767790] Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells [LiteratureReference:9930979] Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas [LiteratureReference:9851265] Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion [LiteratureReference:9931747] Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter [LiteratureReference:9767910] TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer [LiteratureReference:9766002] GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling [LiteratureReference:9765031] Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis [LiteratureReference:9764816] TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer [LiteratureReference:9768099] E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing [LiteratureReference:9759718] Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells [LiteratureReference:9764994] Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion [LiteratureReference:9768053] The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain [LiteratureReference:9764954] EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-? [LiteratureReference:9931147] FOXQ1 promotes esophageal cancer proliferation and metastasis by negatively modulating CDH1 [LiteratureReference:9764959] MUC1-C activates EZH2 expression and function in human cancer cells [LiteratureReference:9768485] E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma [LiteratureReference:9931130] The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101 [LiteratureReference:9765848] MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition [LiteratureReference:9764977] Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development [LiteratureReference:9765058] Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer [LiteratureReference:9768539] Kr�ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion [LiteratureReference:9764915] Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer [LiteratureReference:9930826] High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma [LiteratureReference:9931229] WT1 promotes invasion of NSCLC via suppression of CDH1 [LiteratureReference:9931369] Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition [LiteratureReference:9765107] SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities [LiteratureReference:9765162] HIF-2? promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer [LiteratureReference:9931497] PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition [LiteratureReference:9764769] TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression [LiteratureReference:9768078] Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis [LiteratureReference:9931739] PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions [LiteratureReference:9765763] PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer [LiteratureReference:9766294] CtBP1 overexpression in keratinocytes perturbs skin homeostasis
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Negative Regulation of CDH1 Gene Transcription
orthologousEvent	[Pathway:R-CEL-9764725] Negative Regulation of CDH1 Gene Transcription - Caenorhabditis elegans [Pathway:R-DME-9764725] Negative Regulation of CDH1 Gene Transcription - Drosophila melanogaster [Pathway:R-GGA-9764725] Negative Regulation of CDH1 Gene Transcription - Gallus gallus [Pathway:R-XTR-9764725] Negative Regulation of CDH1 Gene Transcription - Xenopus tropicalis [Pathway:R-DRE-9764725] Negative Regulation of CDH1 Gene Transcription - Danio rerio [Pathway:R-SSC-9764725] Negative Regulation of CDH1 Gene Transcription - Sus scrofa [Pathway:R-BTA-9764725] Negative Regulation of CDH1 Gene Transcription - Bos taurus [Pathway:R-CFA-9764725] Negative Regulation of CDH1 Gene Transcription - Canis familiaris [Pathway:R-RNO-9764725] Negative Regulation of CDH1 Gene Transcription - Rattus norvegicus [Pathway:R-MMU-9764725] Negative Regulation of CDH1 Gene Transcription - Mus musculus
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9764725
summation	[Summation:9931757] Numerous transcription factors have been identified as di...
updateTrackers	[UpdateTracker:9984681] Update Tracker - [Pathway:9764725] Negative Regulation of CDH1 Gene Transcription - v96:[modifyText]

Referrals

(hasEvent)	[Pathway:R-HSA-9764560] Regulation of CDH1 Gene Transcription
(updatedInstance)	[UpdateTracker:9984681] Update Tracker - [Pathway:9764725] Negative Regulation of CDH1 Gene Transcription - v96:[modifyText]

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