Reactome | ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter

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ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter Show undefined attributes

authored	[InstanceEdit:9765752] Orlic-Milacic, Marija, 2022-02-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9765853] Orlic-Milacic, Marija, 2022-02-16
dbId	9765850
displayName	ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter
edited	[InstanceEdit:9931115] Orlic-Milacic, Marija, 2024-12-10
eventOf	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9764778] ZEB1 represses CDH1 gene transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9844052] MPHOSPH8 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-427531] SIRT1 [nucleoplasm] [Complex:R-HSA-9793459] ZEB1:CDH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9765848] MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition [LiteratureReference:9851265] Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter
orthologousEvent	[Reaction:R-GGA-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter - Gallus gallus [Reaction:R-BTA-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter - Bos taurus [Reaction:R-RNO-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter - Rattus norvegicus
output	[Complex:R-HSA-9931121] SIRT1:MPHOSPH8:ZEB1:CDH1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9764741] ZEB1 binds CDH1 gene promoter - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9765850
summation	[Summation:9931122] MPHOSPH8 (also known as M-phase phosphoprotein 8 or MPP8) bi...

Referrals

(hasEvent)	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9764778] ZEB1 represses CDH1 gene transcription

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