Reactome | SNAI1 binds the CDH1 gene

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SNAI1 binds the CDH1 gene Show undefined attributes

authored	[InstanceEdit:9756419] May, Bruce, 2021-10-10
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9756407] May, Bruce, 2021-10-14
dbId	9756414
displayName	SNAI1 binds the CDH1 gene
edited	[InstanceEdit:9756419] May, Bruce, 2021-10-10 [InstanceEdit:9932011] Orlic-Milacic, Marija, 2024-12-15
eventOf	[Pathway:R-HSA-9758919] Epithelial-Mesenchymal Transition (EMT) during gastrulation - Homo sapiens [Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
inferredFrom	[Reaction:R-MMU-9756411] Snai1 binds the Cdh1 (E-Cadherin) gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2980903] SNAI1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9756447] The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells [LiteratureReference:9759718] Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
maxDepth	1
modified	[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
name	SNAI1 binds the CDH1 gene
output	[Complex:R-HSA-9756435] SNAI1:CDH1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9756439] Expression of SNAI1 during gastrulation - Homo sapiens
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9794593] Probst, Simone, 2022-07-18 [InstanceEdit:9796183] Zissel, Lea, 2022-07-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9756414
summation	[Summation:9759755] In cancer cells it has been shown that Snail (SNAI1) protein...
updateTrackers	[UpdateTracker:9939766] Update Tracker - [Reaction:9756414] SNAI1 binds the CDH1 gene - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939766] Update Tracker - [Reaction:9756414] SNAI1 binds the CDH1 gene - v92:[modifyText]
(hasEvent)	[Pathway:R-HSA-9758919] Epithelial-Mesenchymal Transition (EMT) during gastrulation [Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription
(inferredTo)	[Reaction:R-MMU-9756411] Snai1 binds the Cdh1 (E-Cadherin) gene