Reactome | ZEB1 represses CDH1 gene transcription

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ZEB1 represses CDH1 gene transcription Show undefined attributes

authored	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
dbId	9764778
displayName	ZEB1 represses CDH1 gene transcription
edited	[InstanceEdit:9930669] Orlic-Milacic, Marija, 2024-12-05
eventOf	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9764759] ZEB1 recruit Brg1 to regulate airway remodeling epithelial-mesenchymal transition in asthma [LiteratureReference:9764753] Brg1 inhibits E-cadherin expression in lung epithelial cells and disrupts epithelial integrity [LiteratureReference:9764733] ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 [LiteratureReference:9768099] E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing [LiteratureReference:9764769] TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression [LiteratureReference:9815627] TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin [LiteratureReference:9930710] The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells [LiteratureReference:9765789] SET8 induces epithelial?mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 [LiteratureReference:9765848] MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition
maxDepth	1
modified	[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	ZEB1 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-9793365] CDH1 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-9764786] ZEB1 recruits SMARCA4 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9765791] ZEB1 recruits SETD8 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9815610] Negative gene expression regulation by 'ZEB1:CDH1 gene, SMARCA4:ZEB1:CDH1 gene, HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene, (SETD8:ZEB1:CDH1 gene, SIRT1:MPHOSPH8:ZEB1:CDH1 gene) [nucleoplasm]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9764778
summation	[Summation:9815397] Direct repression of CDH1 gene transcription was first de...

Referrals

(hasEvent)	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription
(precedingEvent)	[NegativePrecedingEvent:9954071] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954111] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954075] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954087] Negative relationship: ZEB1 represses CDH1 gene transcription

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