Reactome | ZBTB33 represses CDH1 gene transcription

Schema > BlackBoxEvent > Entries

ZBTB33 represses CDH1 gene transcription Show undefined attributes

authored	[InstanceEdit:9767860] Orlic-Milacic, Marija, 2022-03-01
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9767781] Orlic-Milacic, Marija, 2022-03-01
dbId	9767779
displayName	ZBTB33 represses CDH1 gene transcription
edited	[InstanceEdit:9930985] Orlic-Milacic, Marija, 2024-12-07
eventOf	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9767790] Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells [LiteratureReference:9930973] Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1 [LiteratureReference:9930979] Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas
maxDepth	1
modified	[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	ZBTB33 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-9793365] CDH1 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-9767787] ZBTB33 binds CDH1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9816006] Negative gene expression regulation by 'ZBTB33:CDH1 gene [nucleoplasm]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9767779
summation	[Summation:9816001] ZBTB33 (Kaiso) negatively regulates CDH1 (E-cadherin) gene t...

Referrals

(hasEvent)	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription
(precedingEvent)	[NegativePrecedingEvent:9954099] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954084] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954100] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954096] Negative relationship: ZBTB33 represses CDH1 gene transcription