Reactome | ZEB1 binds CDH1 gene promoter

Schema > Reaction > Entries

ZEB1 binds CDH1 gene promoter Show undefined attributes

authored	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
dbId	9764741
displayName	ZEB1 binds CDH1 gene promoter
edited	[InstanceEdit:9930669] Orlic-Milacic, Marija, 2024-12-05
eventOf	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
followingEvent	[Reaction:R-HSA-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9765791] ZEB1 recruits SETD8 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9764786] ZEB1 recruits SMARCA4 to CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6789836] ZEB1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768537] Evidence for a function of CtBP in epithelial gene regulation and anoikis [LiteratureReference:9764733] ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 [LiteratureReference:9764763] Transcriptional repression of E-cadherin in nickel-exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter [LiteratureReference:9768043] Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion [LiteratureReference:9767843] Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer [LiteratureReference:9767800] SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis [LiteratureReference:9765810] An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer [LiteratureReference:9764769] TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression
maxDepth	1
modified	[InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
name	ZEB1 binds CDH1 gene promoter
output	[Complex:R-HSA-9793459] ZEB1:CDH1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9765973] CTBP1,CTBP2 binds ZEB1 - Homo sapiens
regulatedBy	[PositiveRegulation:9765969] Positive regulation by 'CTBP1,CTBP2:ZEB1 [nucleoplasm]'
regulationReference	[RegulationReference:9765966] Positive regulation by 'CTBP1:ZEB1 [nucleoplasm]' MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9764741
summation	[Summation:9793457] Direct binding of ZEB1 (Zinc finger E-box-binding homeobo...

Referrals

(hasEvent)	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription
(precedingEvent)	[Reaction:R-HSA-9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter [Reaction:R-HSA-9765791] ZEB1 recruits SETD8 to CDH1 gene promoter [Reaction:R-HSA-9764786] ZEB1 recruits SMARCA4 to CDH1 gene promoter [Reaction:R-HSA-9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter

Cite Us!