Reactome | CTBP1,CTBP2 represses CDH1 gene transcription

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CTBP1,CTBP2 represses CDH1 gene transcription Show undefined attributes

authored	[InstanceEdit:9768370] Orlic-Milacic, Marija, 2022-03-11
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9768370] Orlic-Milacic, Marija, 2022-03-11
dbId	9768511
displayName	CTBP1,CTBP2 represses CDH1 gene transcription
edited	[InstanceEdit:9931493] Orlic-Milacic, Marija, 2024-12-12
eventOf	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768555] Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene [LiteratureReference:996734] Coordinated histone modifications mediated by a CtBP co-repressor complex [LiteratureReference:9768534] Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2 [LiteratureReference:9931136] Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence [LiteratureReference:9931739] PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions [LiteratureReference:9931747] Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter [LiteratureReference:9768255] Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3
maxDepth	1
modified	[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	CTBP1,CTBP2 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-9793365] CDH1 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-9768477] CTBP1,CTBP2 binds CDH1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9931749] Negative gene expression regulation by 'CTBP1,CTBP2:CDH1 gene [nucleoplasm]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9768511
summation	[Summation:9816024] Both CTBP1 (Lin et al. 2003; Shi et al. 2003; Alpatov et al....

Referrals

(hasEvent)

[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription

(precedingEvent)