Reactome | PKM and TGIF2 bind CDH1 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:9766059] Orlic-Milacic, Marija, 2022-02-17
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9766059] Orlic-Milacic, Marija, 2022-02-17
dbId	9766062
displayName	PKM and TGIF2 bind CDH1 gene promoter
edited	[InstanceEdit:9931493] Orlic-Milacic, Marija, 2024-12-12
eventOf	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9766065] PKM and TGIF2 repress CDH1 gene transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9756422] CDH1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9931500] PKM [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452977] TGIF2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9766058] Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition [LiteratureReference:9931497] PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition
maxDepth	1
modified	[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	PKM and TGIF2 bind CDH1 gene promoter
output	[Complex:R-HSA-9931501] PKM:TGIF2:CDH1 gene [nucleoplasm]
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9766062
summation	[Summation:9931502] Pyruvate kinase PKM (also known as PKM2) and TGF-beta-induce...

(hasEvent)	[Pathway:R-HSA-9764725] Negative Regulation of CDH1 Gene Transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9766065] PKM and TGIF2 repress CDH1 gene transcription

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