Reactome | IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F

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IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
dbId	447246
displayName	IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
eventOf	[Pathway:R-HSA-448424] Interleukin-17 signaling - Homo sapiens [Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
input	[DefinedSet:R-HSA-447091] IL17A dimer,IL17F dimer,IL17A:IL17F [extracellular region] [EntityWithAccessionedSequence:R-HSA-447176] IL17RA [plasma membrane] [EntityWithAccessionedSequence:R-HSA-447216] IL17RC [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:447173] Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor [LiteratureReference:447188] IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding [LiteratureReference:447165] Cutting edge: interleukin 17 signals through a heteromeric receptor complex [LiteratureReference:448383] Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F
output	[Complex:R-HSA-448403] IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F [plasma membrane]
regulatedBy	[PositiveRegulation:9765934] Positive regulation by '8:IL17RA [plasma membrane]'
regulationReference	[RegulationReference:9765929] Positive regulation by '8:IL17RA [extracellular region]' ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-447246
summation	[Summation:447117] The Interleukin-17 receptor A/C complex is a dimer of Interl...
updateTrackers	[UpdateTracker:9780244] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v63:[modifyText] [UpdateTracker:9780908] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v61:[modifyText] [UpdateTracker:9774911] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v80:[addRegulator, modifyText] [UpdateTracker:9781603] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v60:[add_removeInput, modifyText]

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(updatedInstance)

[UpdateTracker:9780244] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v63:[modifyText]
[UpdateTracker:9780908] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v61:[modifyText]
[UpdateTracker:9774911] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v80:[addRegulator, modifyText]
[UpdateTracker:9781603] Update Tracker - [BlackBoxEvent:447246] IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F - v60:[add_removeInput, modifyText]

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