Reactome | p-Y705, S727 STAT3 dimer binds CD274 gene

Schema > Reaction > Entries

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701538] Rothfels, Karen, 2020-09-26
dbId	9701537
displayName	p-Y705, S727 STAT3 dimer binds CD274 gene
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9701562] CD274 gene expression downstream of ALK signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9701419] CD274 gene [nucleoplasm] [Complex:R-HSA-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701340] PD-L1 [LiteratureReference:9701294] Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y705, S727 STAT3 dimer binds CD274 gene
output	[Complex:R-HSA-9701462] p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9701537
summation	[Summation:9701494] ALK induces expression of the plasma membrane immunosuppress...

(precedingEvent)	[BlackBoxEvent:R-HSA-9701562] CD274 gene expression downstream of ALK signaling
(hasEvent)	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling

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