Reactome | HDACs deacetylate p-STAT3 dimers

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HDACs deacetylate p-STAT3 dimers Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
catalystActivity	[CatalystActivity:9701521] protein lysine deacetylase activity of Histone deacetylase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701566] Rothfels, Karen, 2020-09-26
dbId	9701565
displayName	HDACs deacetylate p-STAT3 dimers
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
input	[Complex:R-HSA-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701374] Stat3 dimerization regulated by reversible acetylation of a single lysine residue
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HDACs deacetylate p-STAT3 dimers
orthologousEvent	[Reaction:R-DDI-9701565] HDACs deacetylate p-STAT3 dimers - Dictyostelium discoideum [Reaction:R-CEL-9701565] HDACs deacetylate p-STAT3 dimers - Caenorhabditis elegans [Reaction:R-DME-9701565] HDACs deacetylate p-STAT3 dimers - Drosophila melanogaster [Reaction:R-GGA-9701565] HDACs deacetylate p-STAT3 dimers - Gallus gallus [Reaction:R-XTR-9701565] HDACs deacetylate p-STAT3 dimers - Xenopus tropicalis [Reaction:R-SSC-9701565] HDACs deacetylate p-STAT3 dimers - Sus scrofa [Reaction:R-BTA-9701565] HDACs deacetylate p-STAT3 dimers - Bos taurus [Reaction:R-CFA-9701565] HDACs deacetylate p-STAT3 dimers - Canis familiaris [Reaction:R-RNO-9701565] HDACs deacetylate p-STAT3 dimers - Rattus norvegicus [Reaction:R-MMU-9701565] HDACs deacetylate p-STAT3 dimers - Mus musculus
output	[SimpleEntity:R-ALL-427486] CH3COO- [nucleoplasm] [Complex:R-HSA-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9701565
summation	[Summation:9701505] HDAC1, 2, and 3 deacetylate lysine 685 of STAT3. Deacetylati...

Referrals

(hasEvent)

[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling