Reactome | AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter

Schema > Reaction > Entries

AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701555] Rothfels, Karen, 2020-09-26
dbId	9701557
displayName	AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling - Homo sapiens
input	[Complex:R-HSA-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9701417] IL2RG gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-351657] SIN3A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3 [LiteratureReference:9701299] IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter
output	[Complex:R-HSA-9701471] SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9701557
summation	[Summation:9701497] Acetylated, phosphorylated STAT3 and SIN3A bind to the IL2RG...

Referrals

(hasEvent)	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling

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