Reactome | CD274 gene expression downstream of ALK signaling

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701563] Rothfels, Karen, 2020-09-26
dbId	9701562
displayName	CD274 gene expression downstream of ALK signaling
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9701419] CD274 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701294] Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1) [LiteratureReference:9701340] PD-L1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CD274 gene expression downstream of ALK signaling
output	[EntityWithAccessionedSequence:R-HSA-3211776] CD274 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9701537] p-Y705, S727 STAT3 dimer binds CD274 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9701542] Positive gene expression regulation by 'p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm]'
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9701562
summation	[Summation:9701495] ALK signaling promotes expression of the CD274 gene by stimu...

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