Reactome | AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene

Schema > Reaction > Entries

authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9851059] Rothfels, Karen, 2023-10-12
dbId	9851058
displayName	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
input	[Complex:R-HSA-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212181] DNMT1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9701417] IL2RG gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701299] IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
maxDepth	1
modified	[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene
output	[Complex:R-HSA-9850883] DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9851058
summation	[Summation:9850805] STAT3 recruits DNMT1 to the IL2RG promoter in NPM1-ALK cells...

(hasEvent)

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