Activation of the STAT3 pathway downstream of ALK signaling ...

created [InstanceEdit:9701897] Rothfels, Karen, 2020-09-28
dbId 9701896
displayName Activation of the STAT3 pathway downstream of ALK signaling ...
schemaClass Summation
text Activation of the STAT3 pathway downstream of ALK signaling contributes to cellular survival by modulating expression of a number of genes involved in apoptosis, immune response and angiogenesis (reviewed in Werner et al, 2009). The STAT3 pathway is particularly important in ALK+ cancers that express ALK fusion proteins, where STAT3 contributes to the repression of a number of tumor suppressor genes, highlighting its role as a critical oncogene (reviewed in Yu et al, 2014; Guanizo et al, 2018).
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