Reactome | IL2RG gene expression downstream of ALK signaling

Schema > BlackBoxEvent > Entries

IL2RG gene expression downstream of ALK signaling Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701555] Rothfels, Karen, 2020-09-26
dbId	9701556
displayName	IL2RG gene expression downstream of ALK signaling
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9701417] IL2RG gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
maxDepth	1
modified	[InstanceEdit:9853043] Rothfels, Karen, 2023-11-09
name	IL2RG gene expression downstream of ALK signaling
output	[EntityWithAccessionedSequence:R-HSA-449139] IL2RG [plasma membrane]
precedingEvent	[Reaction:R-HSA-9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeGeneExpressionRegulation:9701545] Negative gene expression regulation by 'SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9850955] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
regulationReference	[RegulationReference:9850959] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK [RegulationReference:9850957] Negative gene expression regulation by 'SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]' The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9701556
summation	[Summation:9701554] IL2RG gene expression is repressed by a complex of SIN3A and...
updateTrackers	[UpdateTracker:9853282] Update Tracker - [BlackBoxEvent:9701556] IL2RG gene expression downstream of ALK signaling - v87:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9853282] Update Tracker - [BlackBoxEvent:9701556] IL2RG gene expression downstream of ALK signaling - v87:[addRegulator]
(hasEvent)	[Pathway:R-HSA-9701898] STAT3 nuclear events downstream of ALK signaling

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