Activation of the STAT3 pathway downstream of ALK signaling contributes to cellular survival by modulating expression of a number of genes involved in apoptosis, immune response and angiogenesis (reviewed in Werner et al, 2009). The STAT3 pathway is particularly important in ALK+ cancers that express ALK fusion proteins, where STAT3 contributes to the repression of a number of tumor suppressor genes, highlighting its role as a critical oncogene (reviewed in Yu et al, 2014; Guanizo et al, 2018).
Zhao, C, Wasik, MA, Zhang, Q, Werner, MT
Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD
Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H
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