Reactome | STAT3 nuclear events downstream of ALK signaling

STAT3 nuclear events downstream of ALK signaling

Stable Identifier

R-HSA-9701898

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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STAT3 nuclear events downstream of ALK signaling

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Activation of the STAT3 pathway downstream of ALK signaling contributes to cellular survival by modulating expression of a number of genes involved in apoptosis, immune response and angiogenesis (reviewed in Werner et al, 2009). The STAT3 pathway is particularly important in ALK+ cancers that express ALK fusion proteins, where STAT3 contributes to the repression of a number of tumor suppressor genes, highlighting its role as a critical oncogene (reviewed in Yu et al, 2014; Guanizo et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
27879258	Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target Werner, MT, Zhao, C, Zhang, Q, Wasik, MA	Blood	2017
29873274	STAT3: a multifaceted oncoprotein Guanizo, AC, Fernando, CD, Garama, DJ, Gough, DJ	Growth Factors	2018
25342631	Revisiting STAT3 signalling in cancer: new and unexpected biological functions Yu, H, Lee, H, Herrmann, A, Buettner, R, Jove, R	Nat. Rev. Cancer	2014