Reactome | RUNX1:CBFB [nucleoplasm]

Schema > Complex > Entries

RUNX1:CBFB [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-8935998] RUNX1:CBFB:CLDN5 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-8934741] RUNX1:CBFB:PRMT1 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8936000] RUNX1 binds the CLDN5 (Claudin-5) gene promoter - Homo sapiens [Reaction:R-HSA-8935980] RUNX1 binds the OCLN gene promoter - Homo sapiens [Reaction:R-HSA-8935960] RUNX1 binds the TJP1 (ZO-1) gene promoter - Homo sapiens [Reaction:R-HSA-8938930] RUNX1 binds ELF2 - Homo sapiens [Reaction:R-HSA-8938951] RUNX1 binds PAX5 (BSAP) - Homo sapiens [Reaction:R-HSA-8878054] HIPK2 phosphorylates RUNX1 - Homo sapiens [Reaction:R-HSA-8878056] RUNX1:CBFB binds EP300 - Homo sapiens [Reaction:R-HSA-8937989] RUNX1 binds PRC1 complexes - Homo sapiens [Reaction:R-HSA-8938217] RUNX1 binds the SWI/SNF complex - Homo sapiens [Reaction:R-HSA-8938022] RUNX1:CBFB binds the NR4A3 gene promoter - Homo sapiens [Reaction:R-HSA-8938150] RUNX1:CBFB binds the PRKCQ gene promoter - Homo sapiens [Reaction:R-HSA-8938199] RUNX1:CBFB binds the MYL9 gene promoter - Homo sapiens [Reaction:R-HSA-8938328] RUNX1:CBFB binds the NFE2 gene promoter - Homo sapiens [Reaction:R-HSA-8938176] RUNX1:CBFB binds the PF4 gene promoter - Homo sapiens [Reaction:R-HSA-8931981] RUNX1 binds ESR1 - Homo sapiens [Reaction:R-HSA-8877360] RUNX1 binds the IFNG promoter - Homo sapiens [Reaction:R-HSA-8877385] RUNX1 binds intron 1 of IL2RA (CD25) gene - Homo sapiens [Reaction:R-HSA-8877485] RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 - Homo sapiens [Reaction:R-HSA-8877404] RUNX1 binds the promoter of the CTLA4 gene - Homo sapiens [Reaction:R-HSA-8939082] RUNX1 binds the CR1 gene promoter - Homo sapiens [Reaction:R-HSA-8865547] RUNX1:CBFB binds FOXP3 gene - Homo sapiens [Reaction:R-HSA-8938913] RUNX1 binds ELF1 - Homo sapiens [Reaction:R-HSA-8934688] RUNX1:CBFB binds the LIFR gene promoter - Homo sapiens [Reaction:R-HSA-8938231] RUNX1:CBFB binds CREBBP - Homo sapiens [Reaction:R-HSA-8939054] RUNX1 binds the PRKCB gene promoter - Homo sapiens [Reaction:R-HSA-8938389] RUNX1:CBFB binds the LGALS3 gene promoter - Homo sapiens [Reaction:R-HSA-8956639] RUNX1 binds YAP1 - Homo sapiens [Reaction:R-HSA-8956568] RUNX1 binds the core TAL1 complex - Homo sapiens [Reaction:R-HSA-8938053] RUNX1:CBFB binds the SERPINB13 gene promoter - Homo sapiens [Reaction:R-HSA-8955748] RUNX1 binds the SOCS3 gene - Homo sapiens [Reaction:R-HSA-8955822] RUNX1 binds the SOCS4 gene - Homo sapiens [Reaction:R-HSA-8877192] RUNX1 binds FOXP3 - Homo sapiens [Reaction:R-HSA-8934742] RUNX1 binds PRMT1 - Homo sapiens [Reaction:R-HSA-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor - Homo sapiens [Reaction:R-HSA-8877338] RUNX1 and NFATC2 bind the IL2 gene promoter - Homo sapiens [Reaction:R-HSA-8865482] KMT2A (MLL) binds RUNX1 - Homo sapiens
created	[InstanceEdit:8865316] Orlic-Milacic, Marija, 2016-03-21
dbId	8865330
displayName	RUNX1:CBFB [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-8865293] CBFB [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8865295] RUNX1 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-8865330] RUNX1:CBFB [nucleoplasm] - Mus musculus [Complex:R-RNO-8865330] RUNX1:CBFB [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-8865330] RUNX1:CBFB [nucleoplasm] - Canis familiaris [Complex:R-BTA-8865330] RUNX1:CBFB [nucleoplasm] - Bos taurus [Complex:R-SSC-8865330] RUNX1:CBFB [nucleoplasm] - Sus scrofa [Complex:R-DRE-8865330] RUNX1:CBFB [nucleoplasm] - Danio rerio [Complex:R-XTR-8865330] RUNX1:CBFB [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-8865330] RUNX1:CBFB [nucleoplasm] - Gallus gallus [Complex:R-DME-8865330] RUNX1:CBFB [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-8865330] RUNX1:CBFB [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:8865327] Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis
maxDepth	2
memberOf	[CandidateSet:R-HSA-8952092] RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-8938850] RUNX1,RUNX1:CBFB [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:8955517] Orlic-Milacic, Marija, 2017-01-11
name	RUNX1:CBFB
producedByEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8865330

Referrals

(hasComponent)	[Complex:R-HSA-8935998] RUNX1:CBFB:CLDN5 gene [nucleoplasm] [Complex:R-HSA-8935979] RUNX1:CBFB:OCLN gene [nucleoplasm] [Complex:R-HSA-8935959] RUNX1:CBFB:TJP1 gene [nucleoplasm] [Complex:R-HSA-8938928] RUNX1:CBFB:ELF2 [nucleoplasm] [Complex:R-HSA-8938948] RUNX1:CBFB:PAX5 [nucleoplasm] [Complex:R-HSA-8878064] RUNX1:CBFB:EP300 [nucleoplasm] [Complex:R-HSA-8937995] RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] [Complex:R-HSA-8938220] RUNX1:CBFB:SWI/SNF [nucleoplasm] [Complex:R-HSA-8938010] RUNX1:CBFB:NR4A3 gene [nucleoplasm] [Complex:R-HSA-8938154] RUNX1:CBFB:PRKCQ gene [nucleoplasm] [Complex:R-HSA-8938205] RUNX1:CBFB:MYL9 gene [nucleoplasm] [Complex:R-HSA-8938329] RUNX1:CBFB:NFE2 gene [nucleoplasm] [Complex:R-HSA-8938178] RUNX1:CBFB:PF4 gene [nucleoplasm] [Complex:R-HSA-8934741] RUNX1:CBFB:PRMT1 [nucleoplasm] [Complex:R-HSA-8935726] RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] [Complex:R-HSA-8931986] RUNX1:CBFB:ESR1:estrogen [nucleoplasm] [Complex:R-HSA-8877363] RUNX1:CBFB:IFNG gene [nucleoplasm] [Complex:R-HSA-8877382] RUNX1:CBFB:IL2RA gene [nucleoplasm] [Complex:R-HSA-8877483] RUNX1:CBFB:TNFRSF18 gene [nucleoplasm] [Complex:R-HSA-8877405] RUNX1:CBFB:CTLA4 gene [nucleoplasm] [Complex:R-HSA-8877341] RUNX1:CBFB:NFATC2:IL2 gene [nucleoplasm] [Complex:R-HSA-8939080] RUNX1:CBFB:CR1 gene [nucleoplasm] [Complex:R-HSA-8865543] RUNX1:CBFB:FOXP3 gene [nucleoplasm] [Complex:R-HSA-8938916] RUNX1:CBFB:ELF1 [nucleoplasm] [Complex:R-HSA-8934703] RUNX1:CBFB:LIFR gene [nucleoplasm] [Complex:R-HSA-8938230] RUNX1:CBFB:CREBBP [nucleoplasm] [Complex:R-HSA-8939061] RUNX1:CBFB:PRKCB gene [nucleoplasm] [Complex:R-HSA-8938391] RUNX1:CBFB:LGALS3 gene [nucleoplasm] [Complex:R-HSA-8956638] RUNX1:CBFB:YAP1 [nucleoplasm] [Complex:R-HSA-8956549] RUNX1:CBFB:TAL1 core complex [nucleoplasm] [Complex:R-HSA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] [Complex:R-HSA-8956603] MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] [Complex:R-HSA-8956591] RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] [Complex:R-HSA-8938054] RUNX1:CBFB:SERPINB13 gene [nucleoplasm] [Complex:R-HSA-8955750] RUNX1:CBFB:SOCS3 gene [nucleoplasm] [Complex:R-HSA-8955821] RUNX1:CBFB:SOCS4 gene [nucleoplasm] [Complex:R-HSA-8877193] RUNX1:CBFB:FOXP3 [nucleoplasm]
(input)	[Reaction:R-HSA-8936000] RUNX1 binds the CLDN5 (Claudin-5) gene promoter [Reaction:R-HSA-8935980] RUNX1 binds the OCLN gene promoter [Reaction:R-HSA-8935960] RUNX1 binds the TJP1 (ZO-1) gene promoter [Reaction:R-HSA-8938930] RUNX1 binds ELF2 [Reaction:R-HSA-8938951] RUNX1 binds PAX5 (BSAP) [Reaction:R-HSA-8878054] HIPK2 phosphorylates RUNX1 [Reaction:R-HSA-8878056] RUNX1:CBFB binds EP300 [Reaction:R-HSA-8937989] RUNX1 binds PRC1 complexes [Reaction:R-HSA-8938217] RUNX1 binds the SWI/SNF complex [Reaction:R-HSA-8938022] RUNX1:CBFB binds the NR4A3 gene promoter [Reaction:R-HSA-8938150] RUNX1:CBFB binds the PRKCQ gene promoter [Reaction:R-HSA-8938199] RUNX1:CBFB binds the MYL9 gene promoter [Reaction:R-HSA-8938328] RUNX1:CBFB binds the NFE2 gene promoter [Reaction:R-HSA-8938176] RUNX1:CBFB binds the PF4 gene promoter [Reaction:R-HSA-8934742] RUNX1 binds PRMT1 [Reaction:R-HSA-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor [Reaction:R-HSA-8931981] RUNX1 binds ESR1 [Reaction:R-HSA-8877360] RUNX1 binds the IFNG promoter [Reaction:R-HSA-8877385] RUNX1 binds intron 1 of IL2RA (CD25) gene [Reaction:R-HSA-8877485] RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 [Reaction:R-HSA-8877404] RUNX1 binds the promoter of the CTLA4 gene [Reaction:R-HSA-8877338] RUNX1 and NFATC2 bind the IL2 gene promoter [Reaction:R-HSA-8939082] RUNX1 binds the CR1 gene promoter [Reaction:R-HSA-8865547] RUNX1:CBFB binds FOXP3 gene [Reaction:R-HSA-8938913] RUNX1 binds ELF1 [Reaction:R-HSA-8934688] RUNX1:CBFB binds the LIFR gene promoter [Reaction:R-HSA-8938231] RUNX1:CBFB binds CREBBP [Reaction:R-HSA-8939054] RUNX1 binds the PRKCB gene promoter [Reaction:R-HSA-8938389] RUNX1:CBFB binds the LGALS3 gene promoter [Reaction:R-HSA-8956639] RUNX1 binds YAP1 [Reaction:R-HSA-8956568] RUNX1 binds the core TAL1 complex [Reaction:R-HSA-8865482] KMT2A (MLL) binds RUNX1 [Reaction:R-HSA-8938053] RUNX1:CBFB binds the SERPINB13 gene promoter [Reaction:R-HSA-8955748] RUNX1 binds the SOCS3 gene [Reaction:R-HSA-8955822] RUNX1 binds the SOCS4 gene [Reaction:R-HSA-8877192] RUNX1 binds FOXP3
(output)	[Reaction:R-HSA-8865320] CBFB binds RUNX1
(hasMember)	[CandidateSet:R-HSA-8952092] RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] [DefinedSet:R-HSA-8938850] RUNX1,RUNX1:CBFB [nucleoplasm] [DefinedSet:R-HSA-8935716] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:R-HSA-8936009] Positive gene expression regulation by 'RUNX1:CBFB:CLDN5 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8935993] Positive gene expression regulation by 'RUNX1:CBFB:OCLN gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8935974] Positive gene expression regulation by 'RUNX1:CBFB:TJP1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8938035] Positive gene expression regulation by 'RUNX1:CBFB:NR4A3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8938184] Positive gene expression regulation by 'RUNX1:CBFB:PF4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8938340] Positive gene expression regulation by 'RUNX1:CBFB:NFE2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8938164] Positive gene expression regulation by 'RUNX1:CBFB:PRKCQ gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8938204] Positive gene expression regulation by 'RUNX1:CBFB:MYL9 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8932090] Positive gene expression regulation by 'RUNX1:CBFB:ESR1:estrogen:AXIN1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8877373] Positive gene expression regulation by 'RUNX1:CBFB:IFNG gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8939102] Positive gene expression regulation by 'RUNX1:CBFB:CR1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8877395] Negative gene expression regulation by 'RUNX1:CBFB:IL2RA gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8877495] Negative gene expression regulation by 'RUNX1:CBFB:TNFRSF18 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8877418] Negative gene expression regulation by 'RUNX1:CBFB:CTLA4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8877344] Positive gene expression regulation by 'RUNX1:CBFB:NFATC2:IL2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8865551] Positive gene expression regulation by 'RUNX1:CBFB:FOXP3 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8934711] Positive gene expression regulation by 'RUNX1:CBFB:LIFR gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8939069] Positive gene expression regulation by 'RUNX1:CBFB:PRKCB gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8938392] Positive gene expression regulation by 'RUNX1:CBFB:LGALS3 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8938061] Negative gene expression regulation by 'RUNX1:CBFB:SERPINB13 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8955883] Negative gene expression regulation by 'RUNX1:CBFB:SOCS3 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8955897] Negative gene expression regulation by 'RUNX1:CBFB:SOCS4 gene [nucleoplasm]'

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