Reactome | RUNX1:CBFB binds the PF4 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8938180] Orlic-Milacic, Marija, 2016-09-08
dbId	8938176
displayName	RUNX1:CBFB binds the PF4 gene promoter
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8938174] PF4 gene transcription is stimulated by RUNX1:CBFB - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8938181] PF4 gene [nucleoplasm] [Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938179] Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1:CBFB binds the PF4 gene promoter
output	[Complex:R-HSA-8938178] RUNX1:CBFB:PF4 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8938176
summation	[Summation:8938175] The RUNX1:CBFB complex binds to two RUNX1 response elements ...

(precedingEvent)	[BlackBoxEvent:R-HSA-8938174] PF4 gene transcription is stimulated by RUNX1:CBFB
(hasEvent)	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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