Reactome | RUNX1:CBFB binds FOXP3 gene

Schema > Reaction > Entries

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865552] Orlic-Milacic, Marija, 2016-03-22
dbId	8865547
displayName	RUNX1:CBFB binds FOXP3 gene
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8865546] FOXP3 gene expression is stimulated by RUNX1:CBFB - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8865540] FOXP3 Gene [nucleoplasm] [Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8865550] Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1:CBFB binds FOXP3 gene
output	[Complex:R-HSA-8865543] RUNX1:CBFB:FOXP3 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8865547
summation	[Summation:8877185] RUNX1, in complex with CBFB, binds to at least two regulator...

(hasEvent)	[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
(precedingEvent)	[BlackBoxEvent:R-HSA-8865546] FOXP3 gene expression is stimulated by RUNX1:CBFB

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