Reactome | KMT2A (MLL) binds RUNX1

Schema > Reaction > Entries

KMT2A (MLL) binds RUNX1 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865475] Orlic-Milacic, Marija, 2016-03-22
dbId	8865482
displayName	KMT2A (MLL) binds RUNX1
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs - Homo sapiens
followingEvent	[Reaction:R-HSA-8865491] RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1183223] KMT2A [nucleoplasm] [Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8865478] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	KMT2A (MLL) binds RUNX1
orthologousEvent	[Reaction:R-DME-8865482] KMT2A (MLL) binds RUNX1 - Drosophila melanogaster [Reaction:R-GGA-8865482] KMT2A (MLL) binds RUNX1 - Gallus gallus [Reaction:R-XTR-8865482] KMT2A (MLL) binds RUNX1 - Xenopus tropicalis [Reaction:R-DRE-8865482] KMT2A (MLL) binds RUNX1 - Danio rerio [Reaction:R-SSC-8865482] KMT2A (MLL) binds RUNX1 - Sus scrofa [Reaction:R-BTA-8865482] KMT2A (MLL) binds RUNX1 - Bos taurus [Reaction:R-CFA-8865482] KMT2A (MLL) binds RUNX1 - Canis familiaris [Reaction:R-RNO-8865482] KMT2A (MLL) binds RUNX1 - Rattus norvegicus [Reaction:R-MMU-8865482] KMT2A (MLL) binds RUNX1 - Mus musculus
output	[Complex:R-HSA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8865482
summation	[Summation:8865508] Histone methyltransferase KMT2A (MLL) binds to RUNX1 (AML1) ...

Referrals

(hasEvent)	[Pathway:R-HSA-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs
(precedingEvent)	[Reaction:R-HSA-8865491] RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene